{"id":"oxamniquine","rwe":[],"tags":[{"label":"Anthelmintic","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"P02BA02","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Infection by Schistosoma","category":"indication"},{"label":"Approved 1980s","category":"decade"},{"label":"Anthelmintics","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antiparasitic Agents","category":"pharmacology"},{"label":"Antiplatyhelmintic Agents","category":"pharmacology"},{"label":"Schistosomicides","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=OXAMNIQUINE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:40:27.442335+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:40:34.762730+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=OXAMNIQUINE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:40:35.409978+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: DNA inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:40:35.963294+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL847/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:40:35.864324+00:00"}},"allNames":"(+/-)-oxamniquine","offLabel":[],"synonyms":["oxamniquine","(+/-)-Oxamniquine","UK-4271"],"timeline":[{"date":"1980-07-23","type":"positive","source":"DrugCentral","milestone":"FDA approval"}],"aiSummary":"Oxamniquine is a small molecule anthelmintic drug originally developed by and currently owned by a pharmaceutical company. It is used to treat infections caused by Schistosoma, a type of parasitic flatworm. The drug was FDA approved in 1980 and is now off-patent, meaning it is available as a generic medication. Oxamniquine works by interfering with the parasite's ability to reproduce, ultimately leading to its death. As an off-patent medication, it is widely available and used to treat schistosomiasis.","approvals":[{"date":"1980-07-23","orphan":false,"company":"","regulator":"FDA"}],"brandName":"(+/-)-Oxamniquine","ecosystem":[{"indication":"Infection by Schistosoma","otherDrugs":[{"name":"praziquantel","slug":"praziquantel","company":"Bayer Hlthcare"}],"globalPrevalence":null}],"mechanism":{"novelty":"First-in-class","modality":"Small Molecule","drugClass":"Anthelmintic","explanation":"","oneSentence":"","technicalDetail":"Oxamniquine acts as a DNA intercalator, inserting itself into the parasite's DNA and inhibiting the enzyme topoisomerase II, which is essential for DNA replication and transcription."},"commercial":{"launchDate":"1980","_launchSource":"DrugCentral (FDA 1980-07-23, )"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2009","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=OXAMNIQUINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T15:09:53.389622","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:40:38.014863+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"praziquantel","drugSlug":"praziquantel","fdaApproval":"1982-12-29","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"oxamniquine","indications":{"approved":[{"name":"Infection by Schistosoma","source":"DrugCentral","snomedId":10087007,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"praziquantel","brandName":"praziquantel","genericName":"praziquantel","approvalYear":"1982","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"_patentsChecked":true,"crossReferences":{"NUI":"N0000146942","MMSL":"5208","NDDF":"002965","UNII":"0O977R722D","VUID":"4018629","CHEBI":"CHEBI:7819","VANDF":"4018629","INN_ID":"3297","RXNORM":"7778","UMLSCUI":"C0029994","chemblId":"CHEMBL847","ChEMBL_ID":"CHEMBL847","KEGG_DRUG":"D00460","DRUGBANK_ID":"DB01096","PDB_CHEM_ID":" OAQ","PUBCHEM_CID":"4612","SNOMEDCT_US":"714023005","MESH_DESCRIPTOR_UI":"D010073"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":419,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"P02BA02","allCodes":["P02BA02"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturers":0,"_genericFilersChecked":true,"genericManufacturerList":[],"status":"approved","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"1980","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":"1980-07-23T00:00:00.000Z","mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:40:38.014863+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}