{"id":"oxaliplatin-5-fluorouracil-leucovorin","safety":{"commonSideEffects":[{"rate":"75–90","effect":"Peripheral neuropathy"},{"rate":"50–80","effect":"Neutropenia"},{"rate":"40–60","effect":"Anemia"},{"rate":"30–50","effect":"Thrombocytopenia"},{"rate":"60–80","effect":"Nausea and vomiting"},{"rate":"40–60","effect":"Diarrhea"},{"rate":"30–50","effect":"Mucositis"},{"rate":"50–70","effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL414804","moleculeType":"Small molecule","molecularWeight":"395.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Oxaliplatin forms platinum-DNA adducts that prevent DNA replication and transcription, inducing apoptosis in rapidly dividing cells. 5-Fluorouracil (5-FU) is converted to active metabolites that inhibit thymidylate synthase, blocking dTMP synthesis and disrupting DNA synthesis; leucovorin (folinic acid) enhances 5-FU efficacy by stabilizing the 5-FU–thymidylate synthase complex. Together, these agents provide synergistic cytotoxic effects against colorectal and other solid tumors.","oneSentence":"This combination uses oxaliplatin (a platinum-based DNA crosslinker) plus 5-fluorouracil and leucovorin (a thymidylate synthase inhibitor with a folate cofactor) to damage cancer cell DNA and disrupt nucleotide synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:25:03.591Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic colorectal cancer"},{"name":"Adjuvant treatment of stage III colorectal cancer"},{"name":"Advanced gastric cancer"},{"name":"Pancreatic cancer"}]},"trialDetails":[{"nctId":"NCT06948448","phase":"PHASE2","title":"A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer","status":"RECRUITING","sponsor":"Ono Pharmaceutical Co. 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