{"id":"ovitrelle-r-hcg-alfa","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Abdominal pain/discomfort"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"r-hCG alfa mimics the natural LH surge that occurs mid-cycle to complete meiosis I and trigger ovulation of the mature oocyte. It is used in assisted reproductive technology protocols after follicle-stimulating hormone (FSH) stimulation to induce final egg maturation and prepare the ovary for egg retrieval.","oneSentence":"Ovitrelle is a recombinant human chorionic gonadotropin (r-hCG) that binds to luteinizing hormone (LH) receptors to trigger final oocyte maturation and ovulation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:59:10.789Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Final oocyte maturation induction in women undergoing assisted reproductive technology (ART) such as in vitro fertilization (IVF)"},{"name":"Ovulation induction in anovulatory women"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":21,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ovitrelle®","Ovidrel®"],"phase":"marketed","status":"active","brandName":"Ovitrelle® [r-hCG alfa]","genericName":"Ovitrelle® [r-hCG alfa]","companyName":"Merck KGaA, Darmstadt, Germany","companyId":"merck-kgaa-darmstadt-germany","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ovitrelle is a recombinant human chorionic gonadotropin (r-hCG) that binds to luteinizing hormone (LH) receptors to trigger final oocyte maturation and ovulation. Used for Final oocyte maturation induction in women undergoing assisted reproductive technology (ART) cycles, Ovulation induction in anovulatory women.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}