{"id":"ovarian-stimulation-with-rfsh","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Injection site reactions"},{"rate":"15-20","effect":"Abdominal pain/bloating"},{"rate":"5-10","effect":"Nausea"},{"rate":"2-5","effect":"Mild fever"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"rFSH is a recombinant gonadotropin that binds to FSH receptors on granulosa cells in the ovary, promoting follicle development and estrogen production. This controlled ovarian hyperstimulation allows retrieval of multiple mature oocytes for in vitro fertilization or other fertility treatments. The dose and duration are carefully titrated to achieve optimal follicle development while minimizing ovarian hyperstimulation syndrome risk.","oneSentence":"Recombinant follicle-stimulating hormone (rFSH) stimulates the growth and maturation of ovarian follicles to produce multiple eggs for assisted reproductive procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:35:27.674Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ovarian stimulation for assisted reproductive technology (ART) including in vitro fertilization (IVF)"},{"name":"Ovulation induction in anovulatory women"}]},"trialDetails":[{"nctId":"NCT04983173","phase":"PHASE4","title":"INTEnsity of ovariaN Stimulation and Embryo Quality","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2021-11-23","conditions":"Infertility","enrollment":110},{"nctId":"NCT07348757","phase":"","title":"rFSH vs rFSH+rLH in Dydrogesterone-Based Progestin Protocol: A Prospective Study","status":"RECRUITING","sponsor":"Centrum Clinic IVF Center","startDate":"2026-01-05","conditions":"InVitro Fertilization, Gonadotropins","enrollment":300},{"nctId":"NCT07242534","phase":"PHASE4","title":"Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization.","status":"RECRUITING","sponsor":"Fundacion Dexeus","startDate":"2026-01-19","conditions":"Infertility, Obesity","enrollment":62},{"nctId":"NCT07108621","phase":"PHASE3","title":"hCG Priming in Women With Diminished Ovarian Reserve","status":"RECRUITING","sponsor":"Kristine Loessl","startDate":"2025-09","conditions":"Infertility, Female, Ovarian Reserve, In Vitro Fertilization (IVF)","enrollment":80},{"nctId":"NCT06193135","phase":"NA","title":"Usefulness of Corifollitropin α as Alternative to Conventional Daily rFSH Protocols in Oocyte Donors Undergoing Pituitary Suppression With Medroxiprogesterona Acetate (MPA)","status":"RECRUITING","sponsor":"Instituto Valenciano de Infertilidad, IVI VALENCIA","startDate":"2025-07-08","conditions":"Infertility, Female, Reproductive Sterility","enrollment":318},{"nctId":"NCT07128394","phase":"NA","title":"Extra Luteinizing Hormone Improve Embryo Quality in IVF Patients With Low LH During Long GnRH-Agonist Treatment","status":"RECRUITING","sponsor":"Nanjing University","startDate":"2024-02-01","conditions":"Infertility, Female, Luteinizing Hormone (LH)","enrollment":590},{"nctId":"NCT06732843","phase":"","title":"Does Recombinant FSH (rFSH, i.g. Gonal F®) as Compared to Human Menopausal Gonadotrophin (hMG) Affect Telomere Length of Cumulus Cells During Antral Follicle Growth and Impact Blastocyst Status?","status":"RECRUITING","sponsor":"ART Fertility Clinics LLC","startDate":"2025-07-23","conditions":"OVARIAN STIMULATION, Telomere Length, Telomere Length, Mean Leukocyte","enrollment":10},{"nctId":"NCT04773353","phase":"PHASE3","title":"Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Indian Women","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2021-12-03","conditions":"Infertility","enrollment":220},{"nctId":"NCT03741699","phase":"PHASE3","title":"Recombinant LH Prior to Ovarian Stimulation in Poor Ovarian Responders (PRE-LH)","status":"COMPLETED","sponsor":"Instituto Valenciano de Infertilidad, IVI Alicante","startDate":"2019-02-18","conditions":"Infertility, Female","enrollment":88},{"nctId":"NCT03846544","phase":"PHASE4","title":"Double Pick up in Poor Prognosis Women","status":"COMPLETED","sponsor":"CRG UZ Brussel","startDate":"2019-10-01","conditions":"Fertility Disorders","enrollment":48},{"nctId":"NCT06199960","phase":"PHASE3","title":"Dual Ovarian Stimulation (Duostim) and Shanghai Protocols in Poor Ovarian Responders","status":"COMPLETED","sponsor":"Royan Institute","startDate":"2019-08-02","conditions":"Assisted Reproductive Techniques","enrollment":116},{"nctId":"NCT05567731","phase":"NA","title":"Effect of GnRH Agonist Treatment Protocols on Ovarian Reserve","status":"COMPLETED","sponsor":"Tanta University","startDate":"2022-10-15","conditions":"Intracytoplasmic Sperm Injection, GnRH Agonist, Infertility","enrollment":30},{"nctId":"NCT01956123","phase":"PHASE3","title":"Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 2","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2014-03-26","conditions":"Infertility","enrollment":513},{"nctId":"NCT03296527","phase":"PHASE3","title":"Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Pan-Asian Women","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2017-12-01","conditions":"Controlled Ovarian Simulation","enrollment":1011},{"nctId":"NCT03755973","phase":"PHASE4","title":"Effect of Different Ovarian Stimulation Protocols on Endometrial Receptivity","status":"COMPLETED","sponsor":"Instituto Valenciano de Infertilidade de Lisboa","startDate":"2020-01-29","conditions":"Infertility, Female, Endometrial Diseases","enrollment":24},{"nctId":"NCT05864937","phase":"","title":"C677T Methylenetetrahydrofolate Reductase Mutation","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2011-12-01","conditions":"Mutation","enrollment":363},{"nctId":"NCT04446845","phase":"PHASE4","title":"Double Stimulation Followed by a Fresh Embryo Transfer","status":"COMPLETED","sponsor":"Fundación Santiago Dexeus Font","startDate":"2020-10-30","conditions":"Infertility","enrollment":120},{"nctId":"NCT05765968","phase":"NA","title":"Cumulative Live Birth After Double Stimulation Protocol Versus Antagonist Protocol for Poor Ovarian Responders","status":"NOT_YET_RECRUITING","sponsor":"Shandong University","startDate":"2023-03-14","conditions":"Infertility","enrollment":1198},{"nctId":"NCT04643925","phase":"PHASE4","title":"hCG Priming in Women With Low Ovarian Reserve","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2020-12-27","conditions":"Infertility, Female, Ovarian Reserve, In Vitro Fertilization","enrollment":20},{"nctId":"NCT03555942","phase":"NA","title":"Luteal Phase-start Ovarian Stimulation With Corifollitropin Alfa","status":"COMPLETED","sponsor":"Fundacion Dexeus","startDate":"2018-05-08","conditions":"Infertility","enrollment":44},{"nctId":"NCT01956110","phase":"PHASE3","title":"Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 1","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2013-10","conditions":"Infertility","enrollment":1329},{"nctId":"NCT03914651","phase":"NA","title":"CLBR Per Initial Cycle With Different Starting Dose in Aged Patients With Poor Ovarian Reservation: 300IU Versus 150IU","status":"UNKNOWN","sponsor":"Reproductive & Genetic Hospital of CITIC-Xiangya","startDate":"2019-04-23","conditions":"Infertility","enrollment":260},{"nctId":"NCT03423537","phase":"PHASE3","title":"Low-dose HCG as an Adjunct to Ovarian Stimulation in Subfertile Women Undergoing ART","status":"TERMINATED","sponsor":"National and Kapodistrian University of Athens","startDate":"2018-06-01","conditions":"HCG; 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