{"id":"ovarian-stimulation-with-cc-rfsh","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Abdominal bloating and discomfort"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Hot flushes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clomiphene citrate (CC) acts as a selective estrogen receptor modulator that blocks negative feedback on the hypothalamic-pituitary axis, increasing endogenous gonadotropin release. Recombinant follicle-stimulating hormone (rFSH) directly stimulates the FSH receptor on ovarian granulosa cells to promote follicle recruitment and development. Together, this combination enhances ovarian stimulation for assisted reproductive technology.","oneSentence":"CC+rFSH is a combination hormonal therapy that stimulates ovarian follicle development by blocking negative feedback (clomiphene citrate) while directly stimulating follicle growth (recombinant FSH).","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:06.246Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ovarian stimulation for assisted reproductive technology (ART) in women with infertility"}]},"trialDetails":[{"nctId":"NCT04983173","phase":"PHASE4","title":"INTEnsity of ovariaN Stimulation and Embryo Quality","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2021-11-23","conditions":"Infertility","enrollment":110},{"nctId":"NCT06199960","phase":"PHASE3","title":"Dual Ovarian Stimulation (Duostim) and Shanghai Protocols in Poor Ovarian Responders","status":"COMPLETED","sponsor":"Royan Institute","startDate":"2019-08-02","conditions":"Assisted Reproductive Techniques","enrollment":116},{"nctId":"NCT00830492","phase":"PHASE4","title":"Clomiphene Citrate (CC)/Gonadotropin/Gonadotropin Releasing Hormone (GnRH) Antagonist Versus Gonadotropin/GnRH Agonist","status":"COMPLETED","sponsor":"Yazd Research & Clinical Center for Infertility","startDate":"2008-01","conditions":"Ovarian Stimulation","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ovarian Stimulation with CC+rFSH","genericName":"Ovarian Stimulation with CC+rFSH","companyName":"Fundación Santiago Dexeus Font","companyId":"fundaci-n-santiago-dexeus-font","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CC+rFSH is a combination ovarian stimulation protocol that uses clomiphene citrate (CC) to enhance endogenous FSH secretion and exogenous recombinant FSH (rFSH) to directly stimulate follicle development for assisted reproductive technology. Used for Ovarian stimulation for assisted reproductive technology (IVF, ICSI), Infertility treatment in women requiring controlled ovarian hyperstimulation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}