{"id":"ortho-novum-777","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Nausea"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"5-10","effect":"Breakthrough bleeding"},{"rate":"3-5","effect":"Mood changes"},{"rate":"0.3-0.4","effect":"Venous thromboembolism"}]},"_chembl":{"chemblId":"CHEMBL5912922","moleculeType":null,"molecularWeight":"513.60"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination oral contraceptive contains varying doses of norethindrone and ethinyl estradiol across three phases of the menstrual cycle, mimicking natural hormone fluctuations. The progestin and estrogen work synergistically to inhibit the luteinizing hormone (LH) surge required for ovulation, thicken cervical mucus to impede sperm transport, and alter the endometrium to prevent implantation.","oneSentence":"Ortho-Novum 777 is a triphasic oral contraceptive that prevents pregnancy through hormonal suppression of ovulation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:24:47.209Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception / prevention of pregnancy"}]},"trialDetails":[{"nctId":"NCT00000420","phase":"PHASE3","title":"Safety of Estrogens in Lupus: Birth Control Pills","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"1997-06","conditions":"Systemic Lupus Erythematosus","enrollment":350}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":33,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Ortho-Novum 777","genericName":"Ortho-Novum 777","companyName":"NYU Langone Health","companyId":"nyu-langone-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ortho-Novum 777 is a triphasic oral contraceptive that prevents pregnancy through hormonal suppression of ovulation. Used for Contraception / prevention of pregnancy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}