{"id":"original-sevoflurane","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Postoperative nausea and vomiting"},{"rate":"5-15","effect":"Emergence delirium"},{"rate":null,"effect":"Airway irritation"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"}]},"_chembl":{"chemblId":"CHEMBL1200694","moleculeType":"Small molecule","molecularWeight":"200.05"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sevoflurane acts primarily as a positive allosteric modulator of GABA-A receptors and an antagonist of NMDA receptors, leading to depression of the central nervous system. This results in loss of consciousness, amnesia, and analgesia suitable for general anesthesia during surgical procedures. The drug is rapidly absorbed and eliminated via the lungs, allowing for quick induction and recovery.","oneSentence":"Sevoflurane is a volatile anesthetic that enhances inhibitory neurotransmission and suppresses excitatory neurotransmission in the central nervous system to produce anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:59.856Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General anesthesia for induction and maintenance during surgery"},{"name":"Anesthesia in pediatric and adult patients"}]},"trialDetails":[{"nctId":"NCT06069219","phase":"","title":"Pharmacokinetics of Sufentanil After Epidural Administration","status":"COMPLETED","sponsor":"Poznan University of Medical Sciences","startDate":"2019-06-01","conditions":"Epidural; Anesthesia, Epidural Analgesia, Abdominal Surgery","enrollment":18},{"nctId":"NCT01718236","phase":"PHASE4","title":"Modern Myorelaxation Procedure and Reversal of Neuromuscular Blockade With General Anesthesia for Caesarean Section","status":"COMPLETED","sponsor":"Brno University Hospital","startDate":"2012-09","conditions":"Caesarean Section, Pregnancy","enrollment":500},{"nctId":"NCT02301676","phase":"PHASE4","title":"Long Term Postoperative Cognitive Dysfunction in the Elderly Patients","status":"UNKNOWN","sponsor":"Pusan National University Yangsan Hospital","startDate":"2014-12","conditions":"Cognitive Impairment","enrollment":190},{"nctId":"NCT01096212","phase":"PHASE4","title":"Efficacy and Safety of Sevofran in Patients Scheduled for Elective Surgery Under General Anesthesia","status":"COMPLETED","sponsor":"Asan Medical Center","startDate":"2008-09","conditions":"General Anesthesia, Sevoflurane, Generic Drugs","enrollment":178}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sevorane® (Abott Korea Ltd, Seoul, Korea)"],"phase":"marketed","status":"active","brandName":"original sevoflurane","genericName":"original sevoflurane","companyName":"Asan Medical Center","companyId":"asan-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sevoflurane is a volatile anesthetic that enhances inhibitory neurotransmission and suppresses excitatory neurotransmission in the central nervous system to produce anesthesia. Used for General anesthesia for induction and maintenance during surgery, Anesthesia in pediatric and adult patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}