{"id":"oral-prednisone-hospital-dose-steroids","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Hyperglycemia / glucose intolerance"},{"rate":"10-20","effect":"Insomnia / sleep disturbance"},{"rate":"10-20","effect":"Increased appetite / weight gain"},{"rate":"5-15","effect":"Mood changes (irritability, anxiety)"},{"rate":"5-10","effect":"Hypertension"},{"rate":null,"effect":"Osteoporosis (with chronic use)"},{"rate":"variable","effect":"Immunosuppression / increased infection risk"},{"rate":"5-10","effect":"Gastrointestinal upset"},{"rate":"5-10","effect":"Acne / skin changes"}]},"_chembl":{"chemblId":"CHEMBL15720","moleculeType":"Small molecule","molecularWeight":"358.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Prednisone enters cells and binds to cytoplasmic glucocorticoid receptors, which then translocate to the nucleus and modulate gene transcription. This leads to decreased production of inflammatory mediators (cytokines, chemokines, adhesion molecules) and suppression of immune cell activation and proliferation. At higher hospital doses, these anti-inflammatory and immunosuppressive effects are pronounced and used to manage acute inflammatory and autoimmune conditions.","oneSentence":"Prednisone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:46.987Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute inflammatory conditions requiring high-dose corticosteroid therapy"},{"name":"Autoimmune disorders (e.g., lupus, vasculitis)"},{"name":"Severe allergic reactions"},{"name":"Acute exacerbations of chronic inflammatory diseases"},{"name":"Organ transplant rejection prophylaxis"}]},"trialDetails":[{"nctId":"NCT07258771","phase":"PHASE4","title":"Upadacitinib Combined With Corticosteroids vs Corticosteroid Monotherapy Induction for Inpatients and Outpatients With Acute Severe Ulcerative Colitis","status":"RECRUITING","sponsor":"Berinstein, Jeffrey","startDate":"2026-01-16","conditions":"Ulcerative Colitis Acute","enrollment":110},{"nctId":"NCT06315309","phase":"PHASE2","title":"Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell Transplant","status":"RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2025-04-15","conditions":"GVHD,Acute, Acute Leukemia, Myelodysplastic Syndromes","enrollment":29},{"nctId":"NCT06265584","phase":"PHASE2","title":"Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplant","status":"RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2025-04-08","conditions":"Acute Leukemia, Myelodysplastic Syndrome, Myeloproliferative Disorders","enrollment":56},{"nctId":"NCT07049172","phase":"NA","title":"Rituximab and Targeted Nursing for Pediatric Nephrotic Syndrome","status":"COMPLETED","sponsor":"Wuhan Children's Hospital","startDate":"2021-01-01","conditions":"Nephrotic Syndrome in Children","enrollment":91},{"nctId":"NCT05867329","phase":"PHASE4","title":"Feasibility Pilot Sequential Multiple Assignment Randomized Trial (SMART) for Acute Severe Ulcerative Colitis","status":"RECRUITING","sponsor":"Berinstein, Jeffrey","startDate":"2023-09-30","conditions":"Ulcerative Colitis Acute","enrollment":162},{"nctId":"NCT04356430","phase":"PHASE2","title":"Neoadjuvant Therapy of Abiraterone Plus ADT for High Risk Prostate Cancer","status":"UNKNOWN","sponsor":"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","startDate":"2019-04-01","conditions":"Prostate Cancer","enrollment":75},{"nctId":"NCT03692416","phase":"PHASE3","title":"The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2018-11-11","conditions":"Vasculitis","enrollment":70},{"nctId":"NCT02012465","phase":"EARLY_PHASE1","title":"Validation of Insulin Protocol for Glucocorticoid-induced Hyperglycemia in Diabetic Oncology Patients","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2013-09","conditions":"Lymphoma, Diabetes Mellitus, Type 2, Hyperglycemia","enrollment":15},{"nctId":"NCT03018600","phase":"","title":"Continuous Glucose Monitoring on Patients With Active Autoimmune Diseases Following High-dose Predisone Treatment","status":"COMPLETED","sponsor":"Peking Union Medical College Hospital","startDate":"2016-01","conditions":"Glucocorticoid-induced Hyperglycemia","enrollment":25},{"nctId":"NCT00166712","phase":"PHASE4","title":"A Trial of Two Steroid-Free Approaches Toward Mycophenolate Mofetil-Based Monotherapy Immunosuppression","status":"TERMINATED","sponsor":"Northwestern University","startDate":"2005-04","conditions":"Kidney Transplant Failure and Rejection","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":21,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["prednisone"],"phase":"marketed","status":"active","brandName":"Oral Prednisone - Hospital Dose Steroids","genericName":"Oral Prednisone - Hospital Dose Steroids","companyName":"Berinstein, Jeffrey","companyId":"berinstein-jeffrey","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Prednisone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Acute inflammatory conditions requiring high-dose corticosteroid therapy, Autoimmune disorders (e.g., lupus, vasculitis), Severe allergic reactions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}