{"id":"oral-polio-vaccine-information","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaccine-derived poliovirus (VDPV) shedding"},{"rate":null,"effect":"Mild gastrointestinal symptoms"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Rash"}]},"_chembl":{"chemblId":"CHEMBL2108778","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains live attenuated (weakened) poliovirus strains that replicate in the intestinal tract, triggering both mucosal and systemic immune responses. This generates neutralizing antibodies and cellular immunity against wild-type poliovirus, preventing infection and transmission. The oral route allows for intestinal immunity development, which is particularly important for blocking fecal-oral transmission.","oneSentence":"Oral polio vaccine stimulates the immune system to produce antibodies against poliovirus types 1, 2, and 3, providing protection against poliomyelitis infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:37:14.480Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of poliomyelitis (polio) in infants and children"},{"name":"Routine immunization against poliovirus in endemic and non-endemic regions"}]},"trialDetails":[{"nctId":"NCT04445428","phase":"PHASE4","title":"OPV as Potential Protection Against COVID-19","status":"UNKNOWN","sponsor":"Bandim Health Project","startDate":"2020-07-15","conditions":"Poliovirus Vaccine, Oral, COVID, Mortality","enrollment":3400}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"oral polio vaccine + information","genericName":"oral polio vaccine + information","companyName":"Bandim Health Project","companyId":"bandim-health-project","modality":"Biologic","firstApprovalDate":"","aiSummary":"Oral polio vaccine stimulates the immune system to produce antibodies against poliovirus types 1, 2, and 3, providing protection against poliomyelitis infection. Used for Prevention of poliomyelitis (polio) in infants and children, Routine immunization against poliovirus in endemic and non-endemic regions.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}