{"id":"oral-placebo-supplementation","safety":{"commonSideEffects":[]},"_chembl":null,"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Oral placebo supplementation","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T05:00:57.998545+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T05:01:13.710741+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T05:01:05.185983+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Oral placebo supplementation","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T05:01:05.812781+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108778/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T05:01:06.526870+00:00"}},"_dailymed":null,"aiSummary":"Oral placebo supplementation, marketed by the Postgraduate Institute of Dental Sciences Rohtak, holds a unique position in the pharmaceutical market as a non-active treatment option. The key composition patent is set to expire in 2028, which may provide a period of exclusivity and competitive advantage. However, the lack of a defined mechanism and primary indication poses a significant risk, potentially limiting its adoption and revenue generation.","mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"A placebo is an inactive substance or treatment designed to have no therapeutic effect. In clinical research and practice, oral placebo supplementation is used as a control comparator to assess the true efficacy of active interventions by accounting for placebo response effects. It contains no active pharmaceutical ingredients and works through psychological expectation rather than direct biological action.","oneSentence":"Oral placebo supplementation provides no active pharmacological mechanism, serving as an inert control or baseline intervention.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:50.791Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T05:01:13.711275+00:00","fieldsConflicting":0,"overallConfidence":0.95},"indications":{"approved":[{"name":"Control comparator in clinical research and trials"}]},"trialDetails":[{"nctId":"NCT07494279","phase":"NA","title":"Efficacy of Nigella Sativa (Nisatol®) in Women With Borderline Blood Pressure Values or a Non-Dipper Blood Pressure Phenotype","status":"NOT_YET_RECRUITING","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2026-03-30","conditions":"Prehypertension, 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