{"id":"oral-n-acetyl-cystein","safety":{"commonSideEffects":[{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"}]},"_chembl":{"chemblId":"CHEMBL1778338","moleculeType":"Small molecule","molecularWeight":"191.25"},"_dailymed":null,"mechanism":{"_ai_source":"featherless-qwen","explanation":"N-Acetyl Cysteine provides cysteine, a precursor to glutathione, which is a critical intracellular antioxidant. It also functions as a mucolytic by disrupting disulfide bonds in mucus, making it less viscous and easier to clear from the airways.","oneSentence":"N-Acetyl Cysteine acts as an antioxidant and mucolytic agent by replenishing intracellular glutathione levels and breaking disulfide bonds in mucus.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:24:42.978Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic obstructive pulmonary disease (COPD)"},{"name":"Acetaminophen overdose"}]},"trialDetails":[{"nctId":"NCT04959864","phase":"NA","title":"Efficacy Study of a Food Supplement With Myo-inositol, N-Acetyl-Cystein, Zinc and Vitamins on Sperm DNA Fragmentation","status":"RECRUITING","sponsor":"GYNOV","startDate":"2021-07-07","conditions":"Male Infertility","enrollment":72},{"nctId":"NCT01820195","phase":"PHASE3","title":"N-Acetyl Cystein and Contrast Nephropathy","status":"UNKNOWN","sponsor":"Imam Khomeini Hospital","startDate":"2013-03","conditions":"Chronic Kidney Disease Stage 2, Radiographic Contrast Agent Nephropathy","enrollment":549}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Trebon"],"phase":"phase_3","status":"active","brandName":"Oral N-Acetyl Cystein","genericName":"Oral N-Acetyl Cystein","companyName":"Imam Khomeini Hospital","companyId":"imam-khomeini-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"N-Acetyl Cysteine acts as an antioxidant and mucolytic agent by replenishing intracellular glutathione levels and breaking disulfide bonds in mucus. Used for Chronic obstructive pulmonary disease (COPD), Acetaminophen overdose.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}