{"id":"oral-lumbrokinase-dlbs1033","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding or hemorrhage"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lumbrokinase is a serine protease extracted from earthworm (Lumbricus rubellus) that directly degrades fibrin in blood clots and enhances fibrinolysis. It works through multiple pathways including direct fibrin degradation and activation of endogenous fibrinolytic systems, thereby reducing blood viscosity and improving microcirculation. This mechanism makes it useful for thromboembolic and microcirculatory disorders.","oneSentence":"Lumbrokinase is a fibrinolytic enzyme derived from earthworm that breaks down fibrin clots and improves blood flow.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:58:51.740Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thromboembolism and blood stasis-related conditions"},{"name":"Diabetic angiopathy"},{"name":"Cerebrovascular disorders"}]},"trialDetails":[{"nctId":"NCT07475065","phase":"PHASE2, PHASE3","title":"The Effect of Oral DLBS1033 in Patients With Diabetic Polyneuropathy","status":"NOT_YET_RECRUITING","sponsor":"Universitas Sebelas Maret","startDate":"2026-03-01","conditions":"Diabetic Polyneuropathy, Peripheral Nervous System Diseases, Peripheral Neuropathy","enrollment":34},{"nctId":"NCT07121569","phase":"PHASE4","title":"Oral DLBS1033 as Adjunctive Therapy in Acute Ischemic Stroke: Impact on Inflammatory Biomarkers and Outcomes","status":"COMPLETED","sponsor":"Universitas Sebelas Maret","startDate":"2024-07-06","conditions":"Ischemic Stroke, Acute","enrollment":52},{"nctId":"NCT07075289","phase":"PHASE4","title":"Comparing Oral Lumbrokinase DLBS1033 and Betahistine Mesylate in Benign Paroxysmal Positional Vertigo","status":"COMPLETED","sponsor":"Universitas Sebelas Maret","startDate":"2024-04-01","conditions":"Benign Paroxysmal Positional Vertigo (Disorder)","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["DISOLF"],"phase":"marketed","status":"active","brandName":"Oral lumbrokinase DLBS1033","genericName":"Oral lumbrokinase DLBS1033","companyName":"Universitas Sebelas Maret","companyId":"universitas-sebelas-maret","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lumbrokinase is a fibrinolytic enzyme derived from earthworm that breaks down fibrin clots and improves blood flow. Used for Thromboembolism and blood stasis-related conditions, Diabetic angiopathy, Cerebrovascular disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}