{"id":"oral-glycopyrrolate-liquid","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dry mouth"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"2-5%","effect":"Vomiting"},{"rate":"2-5%","effect":"Abdominal pain"},{"rate":"2-5%","effect":"Diarrhea"},{"rate":"2-5%","effect":"Fatigue"},{"rate":"2-5%","effect":"Insomnia"},{"rate":"2-5%","effect":"Muscle weakness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By blocking the action of acetylcholine, glycopyrrolate reduces the amount of saliva, sweat, and mucus produced in the body. This can help to alleviate symptoms such as drooling, sweating, and respiratory secretions. Additionally, glycopyrrolate's anticholinergic effects can help to slow the heart rate and reduce the force of the heart's contractions, which can be beneficial in certain medical conditions.","oneSentence":"Glycopyrrolate is an anticholinergic medication that works by blocking the action of acetylcholine, a neurotransmitter that stimulates the parasympathetic nervous system, thereby reducing secretions and slowing the heart rate.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:24:46.167Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic obstructive pulmonary disease (COPD)"}]},"trialDetails":[{"nctId":"NCT00491894","phase":"PHASE3","title":"Safety and Efficacy Study of Oral Glycopyrrolate Liquid for the Treatment of Pathologic (Chronic Moderate to Severe) Drooling in Pediatric Patients 3 to 18 Years of Age With Cerebral Palsy or Other Neurologic Conditions","status":"COMPLETED","sponsor":"Shionogi","startDate":"2007-03","conditions":"Cerebral Palsy, Neurological Conditions, Mental Retardation","enrollment":137}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Oral Glycopyrrolate Liquid","genericName":"Oral Glycopyrrolate Liquid","companyName":"Shionogi","companyId":"shionogi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Glycopyrrolate is an anticholinergic medication that works by blocking the action of acetylcholine, a neurotransmitter that stimulates the parasympathetic nervous system, thereby reducing secretions and slowing the heart rate. Used for Chronic obstructive pulmonary disease (COPD).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}