{"id":"oral-cholera-vaccine-ocv","safety":{"commonSideEffects":[{"rate":"null","effect":"Pain, redness, or swelling at the injection site"}]},"_chembl":{"chemblId":"CHEMBL2108778","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This is achieved through the administration of inactivated Vibrio cholerae bacteria, which triggers an immune response without causing the disease. The immune system then produces antibodies that can recognize and neutralize the bacteria, providing protection against cholera.","oneSentence":"The Oral Cholera Vaccine (OCV) works by stimulating the body's immune system to produce antibodies against Vibrio cholerae, the bacteria that causes cholera.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:24:38.264Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of cholera in individuals traveling to or living in areas where cholera is common"}]},"trialDetails":[{"nctId":"NCT07487077","phase":"PHASE4","title":"Extended Dosing Intervals Trial for Oral Cholera Vaccine, Kenya","status":"RECRUITING","sponsor":"Albert B. Sabin Vaccine Institute","startDate":"2025-10-31","conditions":"Cholera Vaccination","enrollment":1071},{"nctId":"NCT06455852","phase":"NA","title":"Vaccine- and Infection-derived Correlates of Protection for Cholera.","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-03-02","conditions":"Cholera","enrollment":1221},{"nctId":"NCT07304284","phase":"PHASE3","title":"Trial to Evaluate Immunogenicity Non-Inferiority, Safety and Lot-to-Lot Consistency of Biovac OCV-S to Euvichol®-Plus","status":"RECRUITING","sponsor":"International Vaccine Institute","startDate":"2025-10-31","conditions":"Cholera Vaccination","enrollment":2824},{"nctId":"NCT02499172","phase":"NA","title":"Follow-up of Pregnant Women After a Mass Vaccination of Oral Cholera Vaccine (ShancholTM) in Nsanje Malawi","status":"TERMINATED","sponsor":"Johns Hopkins Bloomberg School of Public Health","startDate":"2015-06","conditions":"Miscarriage, Stillbirth, 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Volunteers","status":"UNKNOWN","sponsor":"Brigham and Women's Hospital","startDate":"2022-12-12","conditions":"Cholera, Cholera Vaccine Toxicity","enrollment":53},{"nctId":"NCT04423159","phase":"NA","title":"Immunological Characteristics of a Population at Risk of Cholera After Oral Cholera Vaccine (CHOVAXIM)","status":"COMPLETED","sponsor":"Centre for Infectious Disease Research in Zambia","startDate":"2016-10-16","conditions":"Diarrhea Infectious","enrollment":225},{"nctId":"NCT03581734","phase":"PHASE3","title":"Immunogenicity of Co-administered Oral Polio Vaccine and Oral Cholera Vaccine","status":"UNKNOWN","sponsor":"International Centre for Diarrhoeal Disease Research, Bangladesh","startDate":"2018-07-01","conditions":"Vaccine Reaction","enrollment":579},{"nctId":"NCT03373669","phase":"PHASE4","title":"Effect of Extended Dose Intervals on the Immune Response to Oral Cholera Vaccine","status":"COMPLETED","sponsor":"Johns Hopkins Bloomberg School of Public 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Regimen With Oral Cholera Vaccine","status":"COMPLETED","sponsor":"Sachin Desai","startDate":"2012-12","conditions":"Cholera","enrollment":426},{"nctId":"NCT01707537","phase":"PHASE1","title":"To Determine the Safety and Immunogenicity of an Oral(Whole Cell) Euvichol Cholera Vaccine in Healthy Adult Men","status":"COMPLETED","sponsor":"EuBiologics Co.,Ltd","startDate":"2012-09","conditions":"Prevention Harmful Effects","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Oral Cholera Vaccine 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Used for Prevention of cholera in individuals traveling to or living in areas where cholera is common.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}