{"id":"oral-cholecalciferol-life-style-counselling","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Hypercalciuria"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Kidney stone formation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cholecalciferol is converted in the liver to 25-hydroxyvitamin D and then in the kidney to the active form 1,25-dihydroxyvitamin D, which acts as a steroid hormone to increase intestinal calcium absorption, regulate serum calcium and phosphate, and modulate immune responses. Lifestyle counselling addresses diet, sun exposure, physical activity, and medication adherence to optimize vitamin D status and clinical outcomes.","oneSentence":"Cholecalciferol (vitamin D3) supplementation restores circulating vitamin D levels to support calcium homeostasis, bone mineralization, and immune function, while lifestyle counselling reinforces adherence and healthy behaviors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:42.787Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin D deficiency"},{"name":"Osteoporosis prevention and treatment"},{"name":"Hypocalcemia"},{"name":"Hypoparathyroidism"}]},"trialDetails":[{"nctId":"NCT07103031","phase":"","title":"Comorbidity-Based Propranolol Use in Pediatric Migraine","status":"COMPLETED","sponsor":"Kayseri University","startDate":"2021-01-01","conditions":"Pediatric Migraine, Migraine Disorders, Brain, Vitamin D Deficiency","enrollment":488},{"nctId":"NCT04025489","phase":"NA","title":"Vitamin D Supplementation on Surrogate Markers of Ageing, Ageing Genes, Glycemic and Metabolic Markers in North India","status":"UNKNOWN","sponsor":"Diabetes Foundation, India","startDate":"2020-03-01","conditions":"Vitamin D Supplementation, PreDiabetes, Aging","enrollment":200},{"nctId":"NCT01436916","phase":"PHASE4","title":"Oral Cholecalciferol in Prevention of Type 2 Diabetes Mellitus","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2011-09","conditions":"Prediabetes, Vitamin D Deficiency","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"oral cholecalciferol + life style counselling","genericName":"oral cholecalciferol + life style counselling","companyName":"Post Graduate Institute of Medical Education and Research, Chandigarh","companyId":"post-graduate-institute-of-medical-education-and-research-chandigarh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cholecalciferol (vitamin D3) supplementation restores circulating vitamin D levels to support calcium homeostasis, bone mineralization, and immune function, while lifestyle counselling reinforces adherence and healthy behaviors. Used for Vitamin D deficiency, Osteoporosis prevention and treatment, Hypocalcemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}