{"id":"oral-chloral-hydrate","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dependence with chronic use"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chloral hydrate is a prodrug that is metabolized to trichloroethanol, which acts as a positive allosteric modulator of GABA-A receptors. This enhancement of GABAergic inhibitory signaling depresses central nervous system activity, producing sedation and hypnotic effects. The drug has been used clinically for over a century as a short-acting sedative for insomnia and procedural sedation.","oneSentence":"Chloral hydrate is a sedative-hypnotic that enhances inhibitory neurotransmission in the central nervous system, primarily through potentiation of GABA receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:42.793Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Insomnia"},{"name":"Procedural sedation"},{"name":"Anxiety"}]},"trialDetails":[{"nctId":"NCT06443632","phase":"NA","title":"WASPE Sleep Adjustment for Children Aged 0-4 Years Undergoing Radiation Therapy","status":"COMPLETED","sponsor":"Shandong Cancer Hospital and Institute","startDate":"2024-06-01","conditions":"Pediatric Cancer","enrollment":48},{"nctId":"NCT06606899","phase":"NA","title":"A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-09-20","conditions":"Sedation for Children Undergoing MRI","enrollment":60},{"nctId":"NCT04820205","phase":"NA","title":"Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Procedural Sedation in Children","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2021-10-29","conditions":"Sedation","enrollment":136},{"nctId":"NCT06389318","phase":"NA","title":"Buccal Midazolam Versus Intranasal Dexmedetomidine Plus Oral Chloral Hydrate in Inguinal Hernia Repair","status":"COMPLETED","sponsor":"Benha University","startDate":"2023-03-26","conditions":"Inguinal Hernia Repair","enrollment":80},{"nctId":"NCT04822064","phase":"NA","title":"Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Rescue After Failed Pediatric Procedural Sedation","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2022-09-22","conditions":"Sedation","enrollment":70},{"nctId":"NCT05492812","phase":"NA","title":"Sedation and Nursing Management in EEG Recording in Children","status":"COMPLETED","sponsor":"Suleyman Demirel University","startDate":"2021-01-01","conditions":"Electroencephalography, Melatonin, Chloral Hydrate","enrollment":180},{"nctId":"NCT02195661","phase":"PHASE3","title":"The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children","status":"COMPLETED","sponsor":"University of Cape Town","startDate":"2014-04","conditions":"Epilepsy, Electroencephalogram, Children","enrollment":194},{"nctId":"NCT03242629","phase":"NA","title":"Comparison Between Oral and Enema of Chloral Hydrate","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2017-01","conditions":"Congenital Cataract","enrollment":120},{"nctId":"NCT02523144","phase":"PHASE4","title":"Dexmedetomidine in Children Having Transthoracic Echocardiography","status":"COMPLETED","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2014-09","conditions":"Heart Disease","enrollment":279},{"nctId":"NCT00464451","phase":"PHASE2","title":"Dexmedetomidine Versus Chloral Hydrate for Pediatric Sedation During EEG","status":"WITHDRAWN","sponsor":"Wesley Medical Center","startDate":"2009-08","conditions":"Procedural Sedation","enrollment":""},{"nctId":"NCT01255904","phase":"PHASE4","title":"A Trial Of Oral Chloral Hydrate Versus Intranasal Dexmedetomidine For Sedated Abr Exams","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2011-08","conditions":"Sedation","enrollment":90},{"nctId":"NCT02253199","phase":"PHASE4","title":"The Effect of Age on the Median Effective Dose (ED50) of Intranasal Dexmedetomidine for Rescue Sedation Following Failed Sedation With Oral Chloral Hydrate During Magnetic Resonance Imaging","status":"COMPLETED","sponsor":"Guangzhou Women and Children's Medical Center","startDate":"2014-10","conditions":"Aged, Drug, Dose-Response Relationship","enrollment":120},{"nctId":"NCT02239445","phase":"PHASE4","title":"Intranasal Dexmedetomidine VS Oral Chloral Hydrate for Rescue Sedation During Magnetic Resonance Imaging","status":"COMPLETED","sponsor":"Guangzhou Women and Children's Medical Center","startDate":"2014-09","conditions":"Administration Related Reaction, Failed Moderate Sedation During Procedure, Chloral Hydrate Adverse Reaction","enrollment":158},{"nctId":"NCT01128270","phase":"PHASE1, PHASE2","title":"Pharmacotoxicology of Trichloroethylene Metabolites","status":"COMPLETED","sponsor":"University of Florida","startDate":"2010-04","conditions":"Healthy","enrollment":27},{"nctId":"NCT01149226","phase":"NA","title":"Effects of Chloral Hydrate on Induction, Maintenance, and Recovery From Sevoflurane Anesthesia in Day-case Pediatric Surgery","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2010-05","conditions":"Pediatric","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":95,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Oral chloral hydrate","genericName":"Oral chloral hydrate","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chloral hydrate is a sedative-hypnotic that enhances inhibitory neurotransmission in the central nervous system, primarily through potentiation of GABA receptors. Used for Insomnia, Procedural sedation, Anxiety.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}