{"id":"oral-capsule-mexiletine-ir","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Ataxia"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Proarrhythmic effects"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mexiletine works by inhibiting fast inward sodium currents in cardiac tissue, which decreases the rate of depolarization and slows conduction velocity. This action suppresses ectopic activity and abnormal automaticity in the heart, making it effective for treating various cardiac arrhythmias. The drug has a rapid onset and short half-life, allowing for flexible dosing.","oneSentence":"Mexiletine is a class IB antiarrhythmic agent that blocks cardiac sodium channels to suppress abnormal electrical activity and restore normal heart rhythm.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:24:45.181Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ventricular arrhythmias"},{"name":"Suppression of premature ventricular contractions"},{"name":"Long QT syndrome (certain forms)"}]},"trialDetails":[{"nctId":"NCT07097701","phase":"PHASE3","title":"An Open-Label, Randomized, Cross-Over Study to Investigate the Efficacy and Safety of Mexiletine PR Compared to Mexiletine IR","status":"RECRUITING","sponsor":"Lupin Ltd.","startDate":"2025-09-03","conditions":"Myotonia","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Oral Capsule Mexiletine (IR)","genericName":"Oral Capsule Mexiletine (IR)","companyName":"Lupin Ltd.","companyId":"lupin-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mexiletine is a class IB antiarrhythmic agent that blocks cardiac sodium channels to suppress abnormal electrical activity and restore normal heart rhythm. Used for Ventricular arrhythmias, Suppression of premature ventricular contractions, Long QT syndrome (certain forms).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}