{"id":"optison-echocardiography-contrast-agent","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Chest pain or discomfort"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Hypersensitivity reactions"}]},"_chembl":{"chemblId":"CHEMBL4802227","moleculeType":"Small molecule","molecularWeight":"274.11"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Optison consists of perfluorocarbon gas-filled microspheres stabilized by a human serum albumin shell. When injected intravenously, these microbubbles circulate through the bloodstream and reflect ultrasound energy, creating enhanced contrast in cardiac chambers and improving visualization of cardiac structures, wall motion, and perfusion during echocardiography.","oneSentence":"Optison is a microbubble contrast agent that reflects ultrasound waves to enhance echocardiographic imaging of the heart.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:31.862Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Echocardiographic contrast enhancement for left ventricular opacification"},{"name":"Improvement of left ventricular border definition in patients with suboptimal echocardiograms"}]},"trialDetails":[{"nctId":"NCT01489176","phase":"PHASE3","title":"Regadenoson Real Time Perfusion Imaging Trial-Optison","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2012-07-31","conditions":"Coronary Artery Disease, Myocardial Perfusion Abnormalities","enrollment":50},{"nctId":"NCT03740997","phase":"PHASE4","title":"Study to Determine Safety and Dosage of OPTISON in Pediatric Participants","status":"COMPLETED","sponsor":"GE Healthcare","startDate":"2020-12-01","conditions":"Transthoracic Echocardiography, Suspected or Known Structural or Functional Cardiac Abnormality","enrollment":39},{"nctId":"NCT00580437","phase":"NA","title":"Pre-operative Evaluation of Kidney & Pancreas Transplant Patients","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2003-05-02","conditions":"Kidney Transplantation, Pancreas Transplantation","enrollment":150},{"nctId":"NCT02300870","phase":"","title":"Myocardial Perfusion Echocardiography to Detect Human Heart Transplant Rejection","status":"TERMINATED","sponsor":"Brigham and Women's Hospital","startDate":"2015-01","conditions":"Heart Transplantation","enrollment":10},{"nctId":"NCT01721447","phase":"PHASE4","title":"Efficacy of Optison Echo Contrast to Detect Thrombus in Left Atrial Appendage","status":"COMPLETED","sponsor":"University of Utah","startDate":"2013-06","conditions":"Atrial Fibrillation","enrollment":100},{"nctId":"NCT00286559","phase":"PHASE1, PHASE2","title":"Assessing Myocardial Blood Flow and Blood Flow Reserve by Transoesophageal Echocardiography (TEE)","status":"WITHDRAWN","sponsor":"University Hospital, Basel, Switzerland","startDate":"2006-08","conditions":"Coronary Artery Disease","enrollment":""},{"nctId":"NCT02014701","phase":"NA","title":"Myocardial Contrast Echocardiography for the Assessment of the Infarct Related Artery & Risk Area in Patients w/ NSTEMI.","status":"UNKNOWN","sponsor":"Cedars-Sinai Medical Center","startDate":"2012-08","conditions":"STEMI","enrollment":100},{"nctId":"NCT00730964","phase":"PHASE4","title":"A Prospective Surveillance Trial to Evaluate the Safety of Optison in Clinical Practice.","status":"COMPLETED","sponsor":"GE Healthcare","startDate":"2008-05","conditions":"Echocardiography","enrollment":1039}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Perflutren Protein-Type A microspheres"],"phase":"marketed","status":"active","brandName":"Optison echocardiography contrast agent","genericName":"Optison echocardiography contrast agent","companyName":"University of Utah","companyId":"university-of-utah","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Optison is a microbubble contrast agent that reflects ultrasound waves to enhance echocardiographic imaging of the heart. Used for Echocardiographic contrast enhancement for left ventricular opacification, Improvement of left ventricular border definition in patients with suboptimal echocardiograms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}