{"id":"oplb","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"oPLB delivers buprenorphine, a partial mu-opioid receptor agonist, in an extended-release formulation to reduce withdrawal symptoms and cravings in patients with opioid dependence. The long-acting delivery system aims to improve treatment adherence and reduce the frequency of dosing compared to daily formulations.","oneSentence":"oPLB is a long-acting buprenorphine formulation designed to provide sustained opioid agonist therapy for opioid use disorder.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:24:39.574Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Opioid use disorder"}]},"trialDetails":[{"nctId":"NCT06233799","phase":"PHASE3","title":"Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder","status":"RECRUITING","sponsor":"National Institute on Drug Abuse (NIDA)","startDate":"2024-07-01","conditions":"Methamphetamine-dependence, Methamphetamine Abuse","enrollment":360}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Placebo tablets"],"phase":"phase_3","status":"active","brandName":"oPLB","genericName":"oPLB","companyName":"National Institute on Drug Abuse (NIDA)","companyId":"national-institute-on-drug-abuse-nida","modality":"Small molecule","firstApprovalDate":"","aiSummary":"oPLB is a long-acting buprenorphine formulation designed to provide sustained opioid agonist therapy for opioid use disorder. Used for Opioid use disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}