{"id":"opium-tincture","safety":{"commonSideEffects":[{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Dependence and tolerance"}]},"_chembl":{"chemblId":"CHEMBL2107914","moleculeType":"Unknown"},"_dailymed":{"setId":"e2a5697a-cc41-4cf1-b3a8-59b0268740d7","title":"OPIUM TINCTURE DEODORIZED (MORPHINE) TINCTURE [EDENBRIDGE PHARMACEUTICALS, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The active alkaloids in opium tincture act as agonists at mu, delta, and kappa opioid receptors, modulating pain perception and emotional response to pain in the central nervous system. These compounds also reduce gastrointestinal motility and secretion, making opium tincture historically useful for diarrhea management. The sedative and anxiolytic properties result from opioid receptor activation in the brain.","oneSentence":"Opium tincture contains alkaloids (primarily morphine and codeine) that bind to opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and antidiarrheal effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:41:20.128Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate pain"},{"name":"Diarrhea (historically; limited modern use)"}]},"trialDetails":[{"nctId":"NCT05690321","phase":"PHASE2","title":"Opium Tincture Against Chronic Diarrhea - Patients","status":"COMPLETED","sponsor":"Asbjørn Mohr Drewes","startDate":"2022-11-17","conditions":"Chronic Diarrhea","enrollment":11},{"nctId":"NCT00444093","phase":"PHASE3","title":"Prospective Randomized Open Label Study of the Treatment of Therapy-associated Diarrhea During Percutaneous Radiation Therapy of the Small Pelvis. - Comparison of Loperamide and Tincture of Opium -","status":"TERMINATED","sponsor":"Philipps University Marburg","startDate":"2007-03-05","conditions":"Diarrhea, Enteritis, Cancer","enrollment":1},{"nctId":"NCT05702190","phase":"NA","title":"Opium Tincture Against Chronic Diarrhea - Healthy","status":"COMPLETED","sponsor":"Asbjørn Mohr Drewes","startDate":"2021-03-09","conditions":"Chronic Diarrhea","enrollment":20},{"nctId":"NCT02502175","phase":"PHASE3","title":"Comparing Opium Tincture (OT) With Methadone for Medication-assisted Treatment of Opioid Use Disorder","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2017-06-22","conditions":"Opioid Dependence","enrollment":204},{"nctId":"NCT02242656","phase":"PHASE3","title":"A Phase III Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Investigational Product MP-101 in Subjects With Short Bowel Syndrome Who Have Had an Inadequate Response to Anti-Diarrheals","status":"WITHDRAWN","sponsor":"Marathon Pharmaceuticals, LLC","startDate":"2014-12","conditions":"Short Bowel Syndrome, Short Gut Syndrome, SBS","enrollment":""},{"nctId":"NCT02246816","phase":"PHASE3","title":"A Open Label Extension Study for Subjects That Complete Study MP-101-CL-001","status":"WITHDRAWN","sponsor":"Marathon Pharmaceuticals, LLC","startDate":"2015-02","conditions":"Short Bowel Syndrome, Short Gut Syndrome, SBS","enrollment":""},{"nctId":"NCT01723722","phase":"PHASE4","title":"Treatment of Neonatal Abstinence Syndrome","status":"COMPLETED","sponsor":"Eastern Maine Medical Center","startDate":"2007-01","conditions":"Neonatal Abstinence Syndrome","enrollment":40}],"_emaApprovals":[],"_faersSignals":[{"count":132,"reaction":"DIARRHOEA"},{"count":79,"reaction":"NAUSEA"},{"count":66,"reaction":"VOMITING"},{"count":50,"reaction":"DEHYDRATION"},{"count":50,"reaction":"DRUG INEFFECTIVE"},{"count":49,"reaction":"FATIGUE"},{"count":44,"reaction":"ABDOMINAL PAIN"},{"count":43,"reaction":"WEIGHT DECREASED"},{"count":38,"reaction":"DECREASED APPETITE"},{"count":30,"reaction":"OFF LABEL USE"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dropizol"],"phase":"marketed","status":"active","brandName":"Opium tincture","genericName":"Opium tincture","companyName":"Asbjørn Mohr Drewes","companyId":"asbj-rn-mohr-drewes","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Opium tincture contains alkaloids (primarily morphine and codeine) that bind to opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and antidiarrheal effects. Used for Moderate pain, Diarrhea (historically; limited modern use).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}