{"id":"opioid-therapy","safety":{"commonSideEffects":[{"rate":"10-30%","effect":"Nausea"},{"rate":"10-30%","effect":"Constipation"},{"rate":"5-20%","effect":"Dizziness"},{"rate":"5-20%","effect":"Vomiting"},{"rate":"5-20%","effect":"Headache"},{"rate":"5-20%","effect":"Somnolence"},{"rate":"5-20%","effect":"Pruritus"},{"rate":"5-20%","effect":"Fatigue"},{"rate":"5-20%","effect":"Dry mouth"},{"rate":"5-20%","effect":"Sedation"}]},"_chembl":{"chemblId":"CHEMBL440626","moleculeType":"Small molecule","molecularWeight":"1268.44"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This binding process activates the receptor, leading to a decrease in the transmission of pain signals to the brain. Opioid therapy can be effective for managing moderate to severe pain, but it carries a risk of dependence and addiction.","oneSentence":"Opioid therapy involves binding to opioid receptors in the brain, spinal cord, and other areas to reduce pain perception.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:24:33.499Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic pain"},{"name":"Cancer pain"}]},"trialDetails":[{"nctId":"NCT04304768","phase":"PHASE4","title":"Opioid, HIV and Immune System","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Miami","startDate":"2020-11-18","conditions":"Immune Defect","enrollment":400},{"nctId":"NCT04216719","phase":"NA","title":"Facilitating Opioid Care Connections","status":"ENROLLING_BY_INVITATION","sponsor":"New York State Psychiatric Institute","startDate":"2020-03-18","conditions":"Opioid Court Model, Medication to Treat Opioid Use Disorder, Opioid Use","enrollment":3440},{"nctId":"NCT07498322","phase":"NA","title":"Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System","status":"NOT_YET_RECRUITING","sponsor":"University of Illinois at Chicago","startDate":"2026-06-01","conditions":"Opiod Use Disorder","enrollment":271031},{"nctId":"NCT04677114","phase":"PHASE2","title":"Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections","status":"COMPLETED","sponsor":"Laura Fanucchi","startDate":"2021-03-16","conditions":"Drug Use, Opioid-use Disorder","enrollment":71},{"nctId":"NCT04751175","phase":"PHASE4","title":"Management of Pain in Lumbar Arthrodesis","status":"COMPLETED","sponsor":"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","startDate":"2013-07-04","conditions":"Pain, Postoperative","enrollment":128},{"nctId":"NCT05674240","phase":"","title":"Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2022-12-06","conditions":"Cancer Pain, Chronic Pain, Cancer Associated Pain","enrollment":30},{"nctId":"NCT06577454","phase":"NA","title":"Measuring the Effects of Neurostimulation on Risky and Ambiguous Decision-Making Capacity in People With and Without Substance Use Disorder","status":"SUSPENDED","sponsor":"National Institute on Drug Abuse (NIDA)","startDate":"2026-04-01","conditions":"Opioid Use Disorder, Healthy Volunteers","enrollment":60},{"nctId":"NCT03745339","phase":"","title":"Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder","status":"RECRUITING","sponsor":"National Institute on Drug Abuse (NIDA)","startDate":"2019-06-07","conditions":"Opioid-Related Disorders, Drug Addiction","enrollment":150},{"nctId":"NCT06496230","phase":"EARLY_PHASE1","title":"Open Trial of Technology-Enhanced Behavioral Intervention for Buprenorphine Retention in Pregnant and Postpartum People","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2024-08-06","conditions":"Opioid Use Disorder, Pregnancy Related","enrollment":15},{"nctId":"NCT05503186","phase":"NA","title":"Text Intervention to Facilitate Secure Storage and Disposal of Prescription Opioids","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2024-06-14","conditions":"Opioid Misuse","enrollment":479},{"nctId":"NCT07361796","phase":"NA","title":"The Analgesic Efficacy and Safety of Venlafaxine for Prevention of Postherpetic Neuralgia in Patients With Acute Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain, Postherpetic Neuralgia","enrollment":832},{"nctId":"NCT06441604","phase":"PHASE2","title":"Extended-release Buprenorphine as a Novel Low-dose Induction Strategy","status":"RECRUITING","sponsor":"Brigham and Women's Hospital","startDate":"2025-10-27","conditions":"Opioid Use Disorder","enrollment":30},{"nctId":"NCT07149870","phase":"NA","title":"Pain Management Teams Using Whole Health to Optimize Function and Safety in Veterans: The TEAMWORK Trial","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2025-11-20","conditions":"Chronic Pain","enrollment":432},{"nctId":"NCT07493499","phase":"NA","title":"Virtual Reality for Postoperative Recovery After Major Abdominal Surgery","status":"RECRUITING","sponsor":"Alexandria University","startDate":"2026-02","conditions":"Abdominal Surgery, Postoperative Recovery, Postoperative Pain","enrollment":60},{"nctId":"NCT07179614","phase":"NA","title":"Kentucky Women's Justice Community Overdose Innovation Network - 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