{"id":"opioid-containing","safety":{"commonSideEffects":[{"rate":"40-60","effect":"Constipation"},{"rate":"20-40","effect":"Nausea"},{"rate":"20-30","effect":"Drowsiness"},{"rate":"15-25","effect":"Dizziness"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Dependence/addiction risk"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Opioids work by activating mu, delta, and kappa opioid receptors, which decreases the release of neurotransmitters involved in pain signaling and alters the emotional response to pain. This results in analgesia and can also produce sedation, euphoria, and respiratory depression depending on the dose and formulation.","oneSentence":"Opioid-containing formulations bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:35:14.674Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe pain (specific indication depends on formulation and strength)"}]},"trialDetails":[{"nctId":"NCT04216719","phase":"NA","title":"Facilitating Opioid Care Connections","status":"ENROLLING_BY_INVITATION","sponsor":"New York State Psychiatric Institute","startDate":"2020-03-18","conditions":"Opioid Court Model, Medication to Treat Opioid Use Disorder, Opioid Use","enrollment":3440},{"nctId":"NCT07361796","phase":"NA","title":"The Analgesic Efficacy and Safety of Venlafaxine for Prevention of Postherpetic Neuralgia in Patients With Acute Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain, Postherpetic Neuralgia","enrollment":832},{"nctId":"NCT07154433","phase":"NA","title":"A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2025-09-01","conditions":"Ankle (Ligaments); Instability (Old Injury), Ankle Sprain, Talus Osteochondral Defect","enrollment":110},{"nctId":"NCT05382091","phase":"PHASE2","title":"Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent Persons","status":"NOT_YET_RECRUITING","sponsor":"Go Medical Industries Pty Ltd","startDate":"2026-07-15","conditions":"Opioid Use Disorder","enrollment":250},{"nctId":"NCT06808737","phase":"NA","title":"Efficacy of Transversus Abdominis Plane Block in Alleviating Acute Appendicitis","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2024-05-08","conditions":"Acute Appendicitis","enrollment":105},{"nctId":"NCT07408193","phase":"EARLY_PHASE1","title":"The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.","status":"NOT_YET_RECRUITING","sponsor":"National and Kapodistrian University of Athens","startDate":"2026-03","conditions":"Opioid-Refractory Chronic Cancer-Related Pain","enrollment":24},{"nctId":"NCT07361822","phase":"NA","title":"Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-30","conditions":"Surgery, Pain Management, Opioid Consumption","enrollment":426},{"nctId":"NCT07404358","phase":"PHASE3","title":"Dalargin for Prevention of Organ Disfunction in High-Risk Abdominal Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Botkin Hospital","startDate":"2025-05-13","conditions":"Postoperative Complications, Multiple Organ Failure, Abdominal Surgery","enrollment":200},{"nctId":"NCT05488847","phase":"PHASE4","title":"Opioid-Free Pain Protocol After Shoulder Arthroplasty","status":"ACTIVE_NOT_RECRUITING","sponsor":"Henry Ford Health System","startDate":"2022-06-25","conditions":"Shoulder Arthropathy, Shoulder Pain","enrollment":83},{"nctId":"NCT07216586","phase":"PHASE4","title":"Zynrelef Versus Adductor Canal Block","status":"NOT_YET_RECRUITING","sponsor":"University of Miami","startDate":"2026-06","conditions":"Knee Osteoarthritis, Arthritis Knee","enrollment":120},{"nctId":"NCT07064564","phase":"PHASE1","title":"iSTEP-N 101b: Pharmacokinetics and Safety Study of Low- and High-Dose Naltrexone Implants vs Monthly Vivitrol in Healthy Volunteers","status":"NOT_YET_RECRUITING","sponsor":"Akyso Therapeutics, LLC","startDate":"2026-04-01","conditions":"Opioid Use Disorder","enrollment":33},{"nctId":"NCT07378046","phase":"NA","title":"The Analgesic Efficacy and Safety of Baclofen in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT07378059","phase":"NA","title":"The Analgesic Efficacy and Safety of Loxoprofen Sodium Patch in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT07370402","phase":"NA","title":"The Analgesic Efficacy and Safety of Flurbiprofen Patch in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT07370389","phase":"NA","title":"The Analgesic Efficacy and Safety of Tulodesvenlafaxine in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT07361809","phase":"NA","title":"The Analgesic Efficacy and Safety of Desvenlafaxine in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT06238128","phase":"NA","title":"Opioid Rapid Response System: Naloxone Training in Communities","status":"COMPLETED","sponsor":"University of Missouri-Columbia","startDate":"2024-05-24","conditions":"Opioid Overdose","enrollment":773},{"nctId":"NCT07357376","phase":"PHASE3","title":"Evaluating Suzetrigine for Pain Control Following TKA","status":"NOT_YET_RECRUITING","sponsor":"AdventHealth","startDate":"2026-03-01","conditions":"Postoperative Pain Following Knee Arthroplasty","enrollment":210},{"nctId":"NCT07307976","phase":"NA","title":"The Analgesic Efficacy and Safety of Crisugabalin in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT04375033","phase":"PHASE4","title":"A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2020-11-03","conditions":"Opioid Use Disorder","enrollment":952},{"nctId":"NCT07327138","phase":"NA","title":"Children's Laughter and Fun Yoga as Adjunctive Pain Relief Following Chemotherapy.","status":"RECRUITING","sponsor":"Bahaa Bou Dargham","startDate":"2025-10-15","conditions":"Acute Lymphoblastic Leukemia ALL","enrollment":60},{"nctId":"NCT07079241","phase":"NA","title":"A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose","status":"RECRUITING","sponsor":"Region Skane","startDate":"2025-09-01","conditions":"Opioid Overdose","enrollment":1000},{"nctId":"NCT05299944","phase":"PHASE2","title":"Reducing Pain and Opioid Use With CBD","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2022-03-08","conditions":"Opioid Use Disorder","enrollment":126},{"nctId":"NCT04452344","phase":"PHASE3","title":"Opioid Analgesic Reduction Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Rutgers, The State University of New Jersey","startDate":"2021-01-04","conditions":"Opioid Use","enrollment":1815},{"nctId":"NCT02025855","phase":"PHASE4","title":"Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit","status":"TERMINATED","sponsor":"Henry Ford Health System","startDate":"2014-01","conditions":"Opioid Use, Unspecified With Withdrawal, Opioid-Induced Disorders, Delirium","enrollment":9},{"nctId":"NCT07073846","phase":"PHASE4","title":"Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.","status":"RECRUITING","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2025-10-06","conditions":"Morbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management","enrollment":104},{"nctId":"NCT04087941","phase":"PHASE2","title":"Efficacy and Safety of VM202 in Painful Diabetic Peripheral Neuropathy -The HOPES Trial","status":"WITHDRAWN","sponsor":"Brigham and Women's Hospital","startDate":"2019-11","conditions":"Painful Diabetic Neuropathy","enrollment":""},{"nctId":"NCT07246447","phase":"NA","title":"Ketodex Versus Opioid Based Anesthesia in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy.","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-11","conditions":"Morbid Obesity","enrollment":8},{"nctId":"NCT06261905","phase":"PHASE1","title":"Vitamin D in OUD: Exploration of Alterations on the Dopamine D2/D3 Receptor System","status":"COMPLETED","sponsor":"Yale University","startDate":"2024-03-13","conditions":"Opioid Use Disorder","enrollment":5},{"nctId":"NCT07043452","phase":"EARLY_PHASE1","title":"Measuring Acute Drug Demand in Humans II","status":"WITHDRAWN","sponsor":"Johns Hopkins University","startDate":"2025-11-15","conditions":"Healthy Volunteers","enrollment":""},{"nctId":"NCT06961058","phase":"NA","title":"Telehealth vs In-Person Evaluation of Addiction Treatment After Visiting the Emergency Department","status":"RECRUITING","sponsor":"University of California, Davis","startDate":"2025-06-03","conditions":"Opioid Use Disorder","enrollment":528},{"nctId":"NCT06343753","phase":"NA","title":"Quality of Recovery After Laparoscopic Cholecystectomy Comparing Opioid Free Analgesia Versus Opioid Free Anesthesia","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-05-01","conditions":"Quality of Recovery, Pain, Postoperative, Elective Laparoscopic Cholecystectomy","enrollment":50},{"nctId":"NCT04173416","phase":"NA","title":"The Youth Opioid Recovery Support (YORS) Intervention","status":"RECRUITING","sponsor":"Potomac Health Foundations","startDate":"2020-02-17","conditions":"Opioid-use Disorder, Medication Adherence","enrollment":150},{"nctId":"NCT05171179","phase":"PHASE3","title":"The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2021-10-22","conditions":"Mammaplasty","enrollment":60},{"nctId":"NCT07182110","phase":"PHASE1","title":"Dexamethasone-Enhanced TAP Block in Lapchole","status":"ACTIVE_NOT_RECRUITING","sponsor":"Makassed General Hospital","startDate":"2025-08-19","conditions":"Laparoscopic Cholecystectomy","enrollment":100},{"nctId":"NCT07163104","phase":"NA","title":"The Effects of Nonpharmacological Methods Used in Subcutaneous Application on Pain, Anxiety, and Fear Levels in Children","status":"ACTIVE_NOT_RECRUITING","sponsor":"Zubeyde Ezgi Ercelik","startDate":"2025-02-10","conditions":"Pediatric Oncology","enrollment":72},{"nctId":"NCT07153614","phase":"NA","title":"Efficacy of Perioperative Opioid Sparing Techniques on Time to Initiation of Chemotherapy","status":"RECRUITING","sponsor":"University of Tennessee Graduate School of Medicine","startDate":"2025-02-03","conditions":"Perioperative Opioid Sparing Techniques","enrollment":200},{"nctId":"NCT06941259","phase":"NA","title":"Effects of Combined Rectus Sheath and Ilioinguinal Nerve Block on Opioid Consumption in HALDN","status":"COMPLETED","sponsor":"Koç University","startDate":"2025-03-30","conditions":"Regional Anesthesia Morbidity","enrollment":66},{"nctId":"NCT03978793","phase":"","title":"MyTPill: A Novel Strategy to Monitor Antiretroviral Adherence Among HIV+ Prescription Opioid Users","status":"COMPLETED","sponsor":"Ohio State University","startDate":"2021-02-01","conditions":"HIV-positive Individuals","enrollment":31},{"nctId":"NCT06733506","phase":"PHASE4","title":"A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs","status":"COMPLETED","sponsor":"Gabriel John Culbert","startDate":"2018-10-01","conditions":"Opioid Use Disorder, Injection Drug Use, Skin and Soft Tissue Infections (SSTIs)","enrollment":56},{"nctId":"NCT06935331","phase":"PHASE4","title":"Prospective Opioid-Free AIS Fusion","status":"NOT_YET_RECRUITING","sponsor":"OrthoCarolina Research Institute, Inc.","startDate":"2025-08-15","conditions":"Adolescent Idiopathic Scoliosis (AIS)","enrollment":58},{"nctId":"NCT04484272","phase":"NA","title":"A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell Disease","status":"RECRUITING","sponsor":"University of Florida","startDate":"2021-04-29","conditions":"Sickle Cell Disease","enrollment":185},{"nctId":"NCT03787628","phase":"PHASE2","title":"Cannabidiol Effects on Craving and Relapse Prevention in Opioid Use Disorder","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2022-05-19","conditions":"Opioid-use Disorder","enrollment":35},{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT06464393","phase":"NA","title":"Opioid-based Versus Opioid-free Endotracheal Intubation","status":"COMPLETED","sponsor":"Aretaieion University Hospital","startDate":"2024-03-20","conditions":"Anesthesia, Anesthesia Intubation, Opioid Use","enrollment":70},{"nctId":"NCT05589753","phase":"PHASE1, PHASE2","title":"Sleep Disordered Breathing With Opioid Use","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2019-05-02","conditions":"Sleep Apnea, Opioid Use, Sleep Disordered Breathing","enrollment":150},{"nctId":"NCT03651804","phase":"PHASE4","title":"Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures","status":"WITHDRAWN","sponsor":"University of California, Davis","startDate":"2019-04-10","conditions":"Vertebral Compression Fracture, Facet Joint Pain","enrollment":""},{"nctId":"NCT06523985","phase":"NA","title":"The Feasibility of Using the PulsePoint to Facilitate Overdose Education and Naloxone Distribution","status":"ENROLLING_BY_INVITATION","sponsor":"Indiana University","startDate":"2024-08-07","conditions":"Carrying Naloxone/Narcan on Their Person or in Their Vehicle, Being Trained to Respond to an Opioid Overdose","enrollment":5000},{"nctId":"NCT07022782","phase":"NA","title":"MEDiterranean Diet-driven Detoxification of OPioid Addicted patiEnts (MED-DOPE)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Aristidis Veskoukis","startDate":"2025-03-10","conditions":"Opioid Addiction","enrollment":40},{"nctId":"NCT06971250","phase":"EARLY_PHASE1","title":"Peripheral KV7 Activation for Pain Relief","status":"COMPLETED","sponsor":"Stefan Heber","startDate":"2025-05-08","conditions":"Pain","enrollment":32},{"nctId":"NCT03532256","phase":"","title":"Post-op Crowd Sourcing Health Data Via Text-messaging","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2019-07-01","conditions":"Orthopedic Surgery, Opioid Use, Acute Injuries Knee","enrollment":127},{"nctId":"NCT06989567","phase":"PHASE3","title":"A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis","status":"NOT_YET_RECRUITING","sponsor":"Asklepion Pharmaceuticals, LLC","startDate":"2025-07-25","conditions":"Sickle Cell Disease","enrollment":120},{"nctId":"NCT04240392","phase":"NA","title":"Treatment of Pregnant Women With OUD","status":"COMPLETED","sponsor":"Yale University","startDate":"2020-06-18","conditions":"Opioid-use Disorder","enrollment":230},{"nctId":"NCT04219540","phase":"PHASE4","title":"Long-acting Buprenorphine vs. Naltrexone Opioid Treatments in CJS-involved Adults","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2021-01-07","conditions":"Opioid-use Disorder","enrollment":675},{"nctId":"NCT06648681","phase":"PHASE2","title":"Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients","status":"NOT_YET_RECRUITING","sponsor":"University of British Columbia","startDate":"2025-05-01","conditions":"Delirium - Postoperative, Cardiac Surgery, Cardiac Surgery Subjects","enrollment":60},{"nctId":"NCT06350786","phase":"NA","title":"Conditioned Open-label Placebos to Facilitate Opioid Reduction in Patients With Chronic Non-cancer Pain","status":"RECRUITING","sponsor":"Cosima Locher","startDate":"2024-06-12","conditions":"Chronic Non-cancer Pain","enrollment":86},{"nctId":"NCT06923540","phase":"PHASE4","title":"Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption","status":"NOT_YET_RECRUITING","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2025-04-28","conditions":"Post Operative Analgesia, Opioid Consumption, Postoperative, Acetaminophen","enrollment":140},{"nctId":"NCT03567356","phase":"NA","title":"Treatment of Opioid Use: Medication Adherence Therapy","status":"COMPLETED","sponsor":"Potomac Health Foundations","startDate":"2019-05-01","conditions":"Opioid Dependence, Opioid-Related Disorders","enrollment":45},{"nctId":"NCT04680221","phase":"PHASE4","title":"Stopping Opioid Overuse in Obstetrics to Halt Exposure Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Missouri, Kansas City","startDate":"2021-03-01","conditions":"Pain, Postoperative, Opioid Use","enrollment":97},{"nctId":"NCT06834854","phase":"PHASE1","title":"Opioid Free Anesthesia in Shoulder Arthroscope","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-03-12","conditions":"Measure Time to First Rescue Analgesia Following Extubation","enrollment":60},{"nctId":"NCT03691935","phase":"PHASE4","title":"Erector Spinae Plane Block (ESPB): in Patients Undergoing Surgery Through a Flank or Anterior Subcostal Incision.","status":"TERMINATED","sponsor":"Milton S. Hershey Medical Center","startDate":"2018-09-28","conditions":"Nephrectomy, Partial Nephrectomy, Incision Site Discomfort","enrollment":20},{"nctId":"NCT06735079","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of REL-1017 As Adjunctive Treatment of Major Depressive Disorder (MDD)","status":"WITHDRAWN","sponsor":"MGGM LLC","startDate":"2024-12-27","conditions":"Major Depressive Disorder (MDD)","enrollment":""},{"nctId":"NCT06812182","phase":"NA","title":"Effect of Nurse Guided Enhanced Recovery Clinical Pathway on Respiratory Infection","status":"COMPLETED","sponsor":"Assiut University","startDate":"2023-05-01","conditions":"Nurse's Role","enrollment":60},{"nctId":"NCT04601480","phase":"NA","title":"PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User Population","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2020-08-26","conditions":"Opioid-use Disorder, Opioid Use, Opioid Abuse","enrollment":309},{"nctId":"NCT03090152","phase":"PHASE4","title":"Minimal Opioid Use After Total Hip Replacement (THR)","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2017-03-08","conditions":"Osteoarthritis, Hip","enrollment":180},{"nctId":"NCT05593341","phase":"NA","title":"Opioid Education in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2022-09-27","conditions":"Arthropathy of Knee, Post Operative Pain, Opioid Use","enrollment":42},{"nctId":"NCT04566250","phase":"NA","title":"Non-Opioid Prescriptions After Arthroscopic Surgery in Canada (NO PAin)","status":"COMPLETED","sponsor":"McMaster University","startDate":"2021-02-24","conditions":"Knee Arthroscopy, Shoulder Arthroscopy","enrollment":200},{"nctId":"NCT06689124","phase":"NA","title":"A Randomized Study Comparing of Three Doses Nebulized Fentanyl in Older Adults","status":"ACTIVE_NOT_RECRUITING","sponsor":"Bangkok Metropolitan Administration Medical College and Vajira Hospital","startDate":"2024-07-01","conditions":"Treatment Side Effects, Musculoskeletal Pain","enrollment":120},{"nctId":"NCT03810495","phase":"PHASE1","title":"The O'Neil Long Acting Naltrexone Implant (OLANI) Pharmacokinetic (PK)/Safety Study in Healthy Volunteers","status":"COMPLETED","sponsor":"Go Medical Industries Pty Ltd","startDate":"2019-04-11","conditions":"Opioid Use Disorder","enrollment":20},{"nctId":"NCT06680609","phase":"EARLY_PHASE1","title":"The Analgesic Efficacy of Nefopam in Orthopedics Surgery","status":"COMPLETED","sponsor":"King Abdullah University Hospital","startDate":"2023-06-01","conditions":"Pain Management, Orthopedic Procedure Pain","enrollment":49},{"nctId":"NCT06650371","phase":"NA","title":"Opioid Free Anesthesia Versus Opioid Based Anesthesia","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2024-11-20","conditions":"Opioid Free Anesthesia, Laparoscopic Bariatric Surgeries","enrollment":36},{"nctId":"NCT06608459","phase":"PHASE2","title":"PEX010-Assisted Therapy for Opioid Use Disorder (OUD): a Feasibility Study","status":"NOT_YET_RECRUITING","sponsor":"Filament Health Corp.","startDate":"2024-12","conditions":"Opioid Use Disorder","enrollment":10},{"nctId":"NCT02804022","phase":"PHASE2","title":"Vital-signs-integrated Patient-assisted Intravenous Opioid Analgesia","status":"ACTIVE_NOT_RECRUITING","sponsor":"KK Women's and Children's Hospital","startDate":"2016-12-29","conditions":"Respiratory Depression","enrollment":20},{"nctId":"NCT06630520","phase":"NA","title":"Intraoperative Periarticular Injection in Arthroscopic Anterior Cruciate Ligament Reconstruction Surgery","status":"COMPLETED","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2022-03-20","conditions":"Anterior Cruciate Ligament (ACL) Tear, Arthroscopic Anterior Cruciate Ligament Reconstruction","enrollment":288},{"nctId":"NCT05387408","phase":"NA","title":"Improving Health and Employment Outcomes Through Workplace Opioid Policies","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2022-05-31","conditions":"Opioid-Related Disorders","enrollment":4939},{"nctId":"NCT02711891","phase":"EARLY_PHASE1","title":"Topical Loperamide Gel for Pain Reduction During Repeat Finger Lancing","status":"COMPLETED","sponsor":"Rush University Medical Center","startDate":"2015-03","conditions":"Pain","enrollment":34},{"nctId":"NCT04760613","phase":"PHASE1, PHASE2","title":"CBD for Chronic Radicular Pain on Chronic Opioid Therapy (COT)","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2022-02-03","conditions":"Radiculopathy","enrollment":14},{"nctId":"NCT06384677","phase":"NA","title":"Comparison of Postoperative Analgesia Methods in Patients Undergoing Major Intraabdominal Surgery","status":"COMPLETED","sponsor":"Marmara University","startDate":"2023-04-20","conditions":"Abdominal Cancer, Abdomen Disease","enrollment":43},{"nctId":"NCT02926482","phase":"NA","title":"Intervention to Expand Opioid Use Disorder Treatment Pharmacotherapy Prescribers","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2016-10-26","conditions":"Opioid-use Disorder","enrollment":76},{"nctId":"NCT06437886","phase":"NA","title":"High-dose Opioid Versus Opioid-sparing Anaesthesia in Cardiac Surgery","status":"ENROLLING_BY_INVITATION","sponsor":"Chinese Academy of Medical Sciences, Fuwai Hospital","startDate":"2024-04-22","conditions":"Cardiac Surgery Patients","enrollment":80},{"nctId":"NCT06485817","phase":"NA","title":"How Stress Alters Opioid Drug Effects","status":"COMPLETED","sponsor":"University of Oslo","startDate":"2021-11-15","conditions":"Motivation, Drug Effect, Stress Reaction","enrollment":80},{"nctId":"NCT04601506","phase":"NA","title":"PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Primary Care Providers","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2020-08-26","conditions":"Opioid-use Disorder, Opioid Use, Opioid Abuse","enrollment":472},{"nctId":"NCT04814433","phase":"PHASE4","title":"Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation","status":"TERMINATED","sponsor":"NYU Langone Health","startDate":"2021-03-24","conditions":"Opioid Pain Medication","enrollment":46},{"nctId":"NCT06442306","phase":"NA","title":"Evaluation of Pain Neuroscience Education for Patients Who Experience Chronic Pain With Concurrent Opioid Dependence","status":"COMPLETED","sponsor":"Wichita State University","startDate":"2020-01-03","conditions":"Chronic Pain, Opioid Dependence","enrollment":21},{"nctId":"NCT06377644","phase":"NA","title":"Comparing the Efficacy of KT vs DN With Conventional Treatment for Improving QOL and Alleviating Pain in Frozen Shoulder","status":"ACTIVE_NOT_RECRUITING","sponsor":"Superior University","startDate":"2024-03-01","conditions":"Frozen Shoulder","enrollment":30},{"nctId":"NCT04902547","phase":"NA","title":"Evaluation of a Patient-Centred, Multidisciplinary Opioid Tapering Program for Individuals With Chronic Non-Cancer Pain on Long Term Opioid Therapy","status":"COMPLETED","sponsor":"University of Manitoba","startDate":"2021-05-01","conditions":"Opioid Use, Opioids; Harmful Use, Hyperalgesia","enrollment":26},{"nctId":"NCT02929589","phase":"PHASE3","title":"Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy","status":"TERMINATED","sponsor":"Mike O'Callaghan Military Hospital","startDate":"2018-07-05","conditions":"Pain, Hernia","enrollment":18},{"nctId":"NCT05087914","phase":"PHASE2","title":"Novel Non-opioid Post-surgical Pain Treatment in Females","status":"WITHDRAWN","sponsor":"Northwestern University","startDate":"2021-11-01","conditions":"Acute Pain, Bunionectomy, Toe Fusion","enrollment":""},{"nctId":"NCT04653506","phase":"NA","title":"Paracetamol / Ibuprofen for Postpartum Pain in the Early Postpartum Period","status":"COMPLETED","sponsor":"Tel-Aviv Sourasky Medical Center","startDate":"2020-11-28","conditions":"Pain","enrollment":107},{"nctId":"NCT06216210","phase":"","title":"Assessing the Impact of Opioid-Free Anesthesia Using the Modified Mulimix Technique.","status":"COMPLETED","sponsor":"Zulekha Hospitals","startDate":"2022-04-22","conditions":"Opioid Use","enrollment":60},{"nctId":"NCT06214533","phase":"NA","title":"Celiac plExus Block to Reduce OpioID Consumption Following Hepato-pancreato-biliary Mini-invasive Surgery","status":"UNKNOWN","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","startDate":"2024-03-01","conditions":"Pancreatic Ductal Adenocarcinoma, Liver, Cancer of, Primary Resectable","enrollment":60},{"nctId":"NCT04144933","phase":"PHASE3","title":"Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Saskatchewan","startDate":"2021-05-15","conditions":"Anesthesia, General Anesthesia, Analgesics, Opioid","enrollment":60},{"nctId":"NCT05859035","phase":"NA","title":"Informational App Development for mHealth for Patient Self-Management of Opioid Use Disorder","status":"UNKNOWN","sponsor":"Biomedical Development Corporation","startDate":"2023-06-29","conditions":"Opioid-Related Disorders","enrollment":25},{"nctId":"NCT03700411","phase":"PHASE4","title":"Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery","status":"COMPLETED","sponsor":"The Institute of Molecular and Translational Medicine, Czech Republic","startDate":"2019-01-07","conditions":"Colorectal Cancer, Circulating Tumor Cell","enrollment":125},{"nctId":"NCT04776928","phase":"NA","title":"Testing a Provider-Level Feedback Intervention to Optimize Postoperative Prescribing","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2022-03-17","conditions":"Opioid Prescribing","enrollment":217},{"nctId":"NCT05384665","phase":"NA","title":"Impact of Opioids on Heart Rate During Rapid Sequence Intubation","status":"TERMINATED","sponsor":"Centre Hospitalier Sud Francilien","startDate":"2023-05-16","conditions":"Rapid Sequence Induction","enrollment":3},{"nctId":"NCT04470050","phase":"PHASE1, PHASE2","title":"Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal","status":"COMPLETED","sponsor":"BioXcel Therapeutics Inc","startDate":"2020-06-09","conditions":"Opioid Withdrawal","enrollment":225},{"nctId":"NCT03824808","phase":"PHASE4","title":"Effect of Perioperative Intravenous Lidocaine Infusion in Robotic-Assisted Urologic Surgery","status":"TERMINATED","sponsor":"University of Missouri-Columbia","startDate":"2019-02-26","conditions":"Kidney Cancer, Prostate Cancer","enrollment":21},{"nctId":"NCT05056753","phase":"NA","title":"Heterodyned Whole-Body Vibration in Treatment of Opioid Withdrawal-Induced Anxiety","status":"COMPLETED","sponsor":"PhotoPharmics, Inc.","startDate":"2022-01-20","conditions":"Opioid-use Disorder","enrollment":80},{"nctId":"NCT05606601","phase":"NA","title":"An Online Intervention Addressing Mental Health and Substance Use in University Students","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2022-09-28","conditions":"Anxiety, Depression, Alcohol Use","enrollment":1489}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":184,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Opioid-Containing","genericName":"Opioid-Containing","companyName":"OrthoCarolina Research Institute, Inc.","companyId":"orthocarolina-research-institute-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Opioid-containing formulations bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and transmission. Used for Moderate to severe pain (specific indication depends on formulation and approval status).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}