{"id":"open-label-h-p-acthar-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Fluid retention"},{"rate":null,"effect":"Mood changes / psychiatric effects"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Acne"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":{"chemblId":"CHEMBL1201610","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Acthar contains purified adrenocorticotropic hormone (ACTH), which binds to melanocortin receptors on adrenocortical cells, triggering the synthesis and secretion of endogenous glucocorticoids and mineralocorticoids. This endogenous steroid production provides anti-inflammatory and immunosuppressive effects. 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