{"id":"opc-41061-tolvaptan","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"10-20%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Fatigue"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL344159","moleculeType":"Small molecule","molecularWeight":"448.95"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By blocking the V2 receptor, tolvaptan reduces water reabsorption in the kidneys, thereby increasing urine production and reducing fluid overload in patients with heart failure and hyponatremia.","oneSentence":"Tolvaptan is a selective, competitive antagonist of the vasopressin V2 receptor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:50:38.221Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hyponatremia in hospitalized patients"},{"name":"Autosomal dominant polycystic kidney disease (ADPKD)"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1610,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"OPC-41061 （Tolvaptan)","genericName":"OPC-41061 （Tolvaptan)","companyName":"Otsuka Pharmaceutical Co., Ltd.","companyId":"otsuka","modality":"Small molecule","firstApprovalDate":"","aiSummary":"OPC-41061 (Tolvaptan) is a small molecule vasopressin V2 receptor antagonist, classified as an antagonist in the drug class. It acts by modulating the vasopressin V2 receptor, which is its molecular target.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}