{"id":"opc-12759-ophthalmic-suspension","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Eye irritation"}]},"_chembl":{"chemblId":"CHEMBL4742102","moleculeType":"Unknown","molecularWeight":"421.59"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"OPC-12759 works by stimulating the lacrimal gland to produce more tears, which helps to alleviate dry eye symptoms. This is achieved through its mechanism of action, which involves the stimulation of the lacrimal gland's secretory function. By increasing tear production, OPC-12759 helps to restore the health and integrity of the ocular surface.","oneSentence":"OPC-12759 is an ophthalmic suspension used to treat dry eye syndrome by increasing tear production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:24:24.691Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of dry eye syndrome"}]},"trialDetails":[{"nctId":"NCT01471093","phase":"PHASE1","title":"Safety Study of OPC-12759 Ophthalmic Solution","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Co., Ltd.","startDate":"2011-11","conditions":"Dry Eye Syndromes","enrollment":100},{"nctId":"NCT01660256","phase":"PHASE3","title":"Confirmatory Study of OPC-12759 Ophthalmic Solution","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Co., Ltd.","startDate":"2012-08","conditions":"Dry Eye","enrollment":209},{"nctId":"NCT01493180","phase":"PHASE2","title":"Exploratory Study of OPC-12759 Ophthalmic Suspension","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Co., Ltd.","startDate":"2011-12","conditions":"Keratoconjunctival Epithelial Disorder","enrollment":102},{"nctId":"NCT00234078","phase":"PHASE2","title":"Dose-response Study of OPC-12759 Ophthalmic Suspension","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Co., Ltd.","startDate":"2005-01","conditions":"Dry Eye Syndromes","enrollment":290},{"nctId":"NCT00818324","phase":"PHASE3","title":"Long Term Administration Study of OPC-12759 Ophthalmic Suspension","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Co., Ltd.","startDate":"2009-01","conditions":"Dry Eye Syndromes","enrollment":154},{"nctId":"NCT00885079","phase":"PHASE3","title":"Confirmatory Study of OPC-12759 Ophthalmic Suspension","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Co., Ltd.","startDate":"2009-05","conditions":"Dry Eye Syndromes","enrollment":188},{"nctId":"NCT00475319","phase":"PHASE2","title":"Late Phase 2 Study of OPC-12759 Ophthalmic Suspension","status":"COMPLETED","sponsor":"Otsuka Pharmaceutical Co., Ltd.","startDate":"2007-05","conditions":"Dry Eye Syndromes","enrollment":308},{"nctId":"NCT01057147","phase":"PHASE2","title":"Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Subjects With Dry Eye - Effects on Central Cornea","status":"COMPLETED","sponsor":"Kubota Vision Inc.","startDate":"2010-02","conditions":"Keratoconjunctivitis Sicca, Dry Eye","enrollment":116},{"nctId":"NCT01027013","phase":"PHASE2","title":"Safety and Efficacy Study of Rebamipide 2% Ophthalmic Suspension in Patients With Dry Eye","status":"COMPLETED","sponsor":"Kubota Vision Inc.","startDate":"2009-12","conditions":"Dry Eye Syndromes, Keratoconjunctivitis Sicca","enrollment":220}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":35,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"OPC-12759 Ophthalmic suspension","genericName":"OPC-12759 Ophthalmic suspension","companyName":"Otsuka Pharmaceutical Co., Ltd.","companyId":"otsuka","modality":"Small molecule","firstApprovalDate":"","aiSummary":"OPC-12759 is an ophthalmic suspension used to treat dry eye syndrome by increasing tear production. Used for Treatment of dry eye syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}