{"id":"onion-extract-gel-contractubex","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The onion extract component has anti-inflammatory and antimicrobial properties, while heparin inhibits fibroblast proliferation and collagen deposition, and allantoin promotes wound healing and epithelialization. Together, these ingredients work to soften existing scars, reduce erythema, and prevent excessive collagen accumulation during wound healing.","oneSentence":"Contractubex™ is a topical gel containing onion extract (Cepa), heparin, and allantoin that reduces scar formation and improves scar appearance through anti-inflammatory and tissue remodeling effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:24:18.660Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertrophic and keloid scars"},{"name":"Post-surgical scars"},{"name":"Burn scars"}]},"trialDetails":[{"nctId":"NCT01861119","phase":"PHASE3","title":"Silicone Gel Versus Onion Extract Gel as Prevention for Postsurgical Scars","status":"COMPLETED","sponsor":"CHA University","startDate":"2013-04-01","conditions":"Hypertrophic or Keloid Scars","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Onion extract gel Contractubex™","genericName":"Onion extract gel Contractubex™","companyName":"CHA University","companyId":"cha-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Contractubex™ is a topical gel containing onion extract (Cepa), heparin, and allantoin that reduces scar formation and improves scar appearance through anti-inflammatory and tissue remodeling effects. Used for Hypertrophic and keloid scars, Post-surgical scars, Burn scars.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}