{"id":"one-dose-of-cefo-perazone-sulbactum","safety":{"commonSideEffects":[{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea/vomiting"},{"rate":null,"effect":"Hypersensitivity reactions"},{"rate":null,"effect":"Elevated liver enzymes"},{"rate":null,"effect":"Phlebitis at injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cefoperazone is a third-generation cephalosporin that binds to penicillin-binding proteins and disrupts bacterial cell wall cross-linking, leading to cell lysis. Sulbactam is a beta-lactamase inhibitor that protects cefoperazone from degradation by bacterial beta-lactamases, extending its spectrum of activity against beta-lactamase-producing organisms. This combination is effective against a broad range of gram-positive and gram-negative bacteria.","oneSentence":"Cefoperazone/sulbactam is a beta-lactam antibiotic combined with a beta-lactamase inhibitor that kills bacteria by inhibiting cell wall synthesis while protecting against enzymatic degradation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:24:18.587Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections (respiratory tract, urinary tract, intra-abdominal, skin and soft tissue infections)"},{"name":"Perioperative prophylaxis in gastrointestinal surgery"}]},"trialDetails":[{"nctId":"NCT03784365","phase":"PHASE3","title":"Single-Versus Multiple-dose Antimicrobial Prophylaxis for Peroral Endoscopic Myotomy in Achalasia","status":"UNKNOWN","sponsor":"Asian Institute of Gastroenterology, India","startDate":"2018-12-01","conditions":"Achalasia Cardia","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Multiple doses of Cefo-perazone Sulbactum"],"phase":"phase_3","status":"active","brandName":"One dose of Cefo-perazone Sulbactum","genericName":"One dose of Cefo-perazone Sulbactum","companyName":"Asian Institute of Gastroenterology, India","companyId":"asian-institute-of-gastroenterology-india","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cefoperazone/sulbactam is a beta-lactam antibiotic combined with a beta-lactamase inhibitor that kills bacteria by inhibiting cell wall synthesis while protecting against enzymatic degradation. Used for Bacterial infections (respiratory tract, urinary tract, intra-abdominal, skin and soft tissue infections), Perioperative prophylaxis in gastrointestinal surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}