{"id":"ondansetron-zofran","safety":{"commonSideEffects":[{"rate":"9-27","effect":"Headache"},{"rate":"5-11","effect":"Constipation"},{"rate":"2-8","effect":"Diarrhea"},{"rate":"7-13","effect":"Fatigue"},{"rate":"4-7","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1201111","moleculeType":"Small molecule","molecularWeight":"329.83"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ondansetron is a selective antagonist of serotonin 5-HT3 receptors, which are located in the chemoreceptor trigger zone and on vagal afferent fibers in the gastrointestinal tract. By blocking these receptors, it prevents the transmission of emetic signals to the vomiting center in the brain. This mechanism makes it particularly effective for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).","oneSentence":"Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:22.544Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV)"},{"name":"Postoperative nausea and vomiting (PONV)"},{"name":"Radiation-induced nausea and vomiting"}]},"trialDetails":[{"nctId":"NCT07498751","phase":"PHASE1","title":"Phase I PK and Safety Study of Ondansetron Inhalation Powder","status":"COMPLETED","sponsor":"Luxena Pharmaceuticals, Inc.","startDate":"2025-03-13","conditions":"Postoperative Nausea and Vomiting","enrollment":24},{"nctId":"NCT07489742","phase":"NA","title":"Ondansetron Lozenge Versus Intravenous for Prevention of Shivering in 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