{"id":"ondansetron-orodispersible-film-once","safety":{"commonSideEffects":[{"rate":"9-27%","effect":"Headache"},{"rate":"5-25%","effect":"Constipation"},{"rate":"3-12%","effect":"Diarrhea"},{"rate":"5-13%","effect":"Fatigue"},{"rate":"4-7%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ondansetron is a selective antagonist of serotonin 5-HT3 receptors, which are located in the chemoreceptor trigger zone and on vagal afferent fibers in the gastrointestinal tract. By blocking these receptors, it prevents the transmission of emetic signals to the vomiting center in the brainstem. The orodispersible film formulation allows rapid dissolution and absorption in the oral cavity for faster onset of action.","oneSentence":"Ondansetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:26.780Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of nausea and vomiting induced by chemotherapy"},{"name":"Prevention of postoperative nausea and vomiting"},{"name":"Prevention of radiation-induced nausea and vomiting"}]},"trialDetails":[{"nctId":"NCT07217600","phase":"PHASE4","title":"Ondansetron Orodispersible Film for Vomiting Prevention in Pediatric Radiotherapy","status":"RECRUITING","sponsor":"Chongqing University Cancer Hospital","startDate":"2025-03-25","conditions":"Radiotherapy-induced Nausea and Vomiting (RINV), Pediatric Cancer","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ondansetron orodispersible film once","genericName":"Ondansetron orodispersible film once","companyName":"Chongqing University Cancer Hospital","companyId":"chongqing-university-cancer-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ondansetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting. Used for Prevention of nausea and vomiting induced by chemotherapy, Prevention of postoperative nausea and vomiting, Prevention of radiation-induced nausea and vomiting.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}