{"id":"ondansetron-oral-tablets","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Constipation"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This is achieved through the antagonism of 5-HT3 receptors in the central nervous system and the gastrointestinal tract. By blocking these receptors, ondansetron reduces the vomiting reflex and alleviates nausea.","oneSentence":"Ondansetron works by blocking serotonin receptors in the body, which helps to reduce nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:24:21.184Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of nausea and vomiting caused by cancer chemotherapy"},{"name":"Prevention of nausea and vomiting caused by radiation therapy"}]},"trialDetails":[{"nctId":"NCT07498751","phase":"PHASE1","title":"Phase I PK and Safety Study of Ondansetron Inhalation Powder","status":"COMPLETED","sponsor":"Luxena Pharmaceuticals, Inc.","startDate":"2025-03-13","conditions":"Postoperative Nausea and Vomiting","enrollment":24},{"nctId":"NCT07458282","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-10","conditions":"Laparoscopic Surgery, Liposomal Bupivacaine, Transversus Abdominis Plane Block","enrollment":318},{"nctId":"NCT07458295","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-10","conditions":"Laparoscopic Surgery, Gynecologic Oncology Patient, Liposomal Bupivacaine","enrollment":110},{"nctId":"NCT07458256","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-10","conditions":"Laparoscopic Surgery, Liposomal Bupivacaine, Local Infiltration","enrollment":190},{"nctId":"NCT06780202","phase":"PHASE2","title":"Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients","status":"RECRUITING","sponsor":"Emory University","startDate":"2025-01-27","conditions":"Foot Injuries and Disorders, Ankle Injuries and Disorders, Achilles Tendon Injury","enrollment":180},{"nctId":"NCT07432711","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-02","conditions":"Video-assisted Thoracoscopic Surgery (VATS), Pain Management, Liposomal Bupivacaine","enrollment":100},{"nctId":"NCT07442539","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Hemorrhoid Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-02","conditions":"Hemorrhoid Surgery, Liposome Bupivacaine, Pain Management","enrollment":156},{"nctId":"NCT07441902","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-02","conditions":"Video-assisted Thoracoscopic Surgery (VATS), Pain Management, Liposomal Bupivacaine","enrollment":134},{"nctId":"NCT07310563","phase":"PHASE1","title":"A Trial to Evaluate Interactions Between Antiemetic Medication and AMG 133 in Participants Living With Overweight or Obesity","status":"COMPLETED","sponsor":"Amgen","startDate":"2024-12-10","conditions":"Overweight, Obesity","enrollment":59},{"nctId":"NCT05418244","phase":"PHASE2, PHASE3","title":"Inhaled Isopropyl Alcohol for Treatment of Nausea","status":"RECRUITING","sponsor":"State University of New York at Buffalo","startDate":"2022-04-20","conditions":"Vomiting, Nausea, Children, Only","enrollment":84},{"nctId":"NCT07124195","phase":"PHASE3","title":"Nanocrystalline Megestrol for Managing Chemotherapy-Induced Nausea and Vomiting","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital of Xinxiang Medical College","startDate":"2025-08-10","conditions":"Malignant Solid Tumors, Moderate to High Emetogenic Chemotherapy (MEC/HEC) Drugs","enrollment":126},{"nctId":"NCT03593811","phase":"EARLY_PHASE1","title":"Noninvasive Markers of Functional Nausea in Children","status":"ACTIVE_NOT_RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2018-08-03","conditions":"Nausea","enrollment":42},{"nctId":"NCT03030417","phase":"PHASE1","title":"Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2017-02-27","conditions":"Solid Tumors, Lymphoma","enrollment":36},{"nctId":"NCT03475693","phase":"EARLY_PHASE1","title":"A Cohort Study Evaluating the Efficacy of PO Magnesium in the Treatment of Acute Traumatic Brain Injury in Adolescents","status":"COMPLETED","sponsor":"Corewell Health South","startDate":"2017-09-01","conditions":"Concussion Post Syndrome","enrollment":17},{"nctId":"NCT00934180","phase":"PHASE1","title":"Ondansetron HCl Orally Disintegrating Tablets Under Fasting Conditions","status":"COMPLETED","sponsor":"Teva Pharmaceuticals USA","startDate":"2002-12","conditions":"Healthy","enrollment":24},{"nctId":"NCT00934921","phase":"PHASE1","title":"Ondansetron HCl Orally Disintegrating Tablets Under Non-Fasting Conditions","status":"COMPLETED","sponsor":"Teva Pharmaceuticals USA","startDate":"2003-02","conditions":"Healthy","enrollment":24},{"nctId":"NCT03642964","phase":"PHASE2","title":"A Study in Patients With Major Depressive Disorder","status":"ACTIVE_NOT_RECRUITING","sponsor":"Chase Therapeutics Corporation","startDate":"2018-09-10","conditions":"Major Depressive Disorder (MDD)","enrollment":24},{"nctId":"NCT00649363","phase":"PHASE1","title":"Fasting Study of Ondansetron Orally Disintegrating Tablets 8 mg to Zofran ODT® Tablets 8 mg","status":"COMPLETED","sponsor":"Mylan Pharmaceuticals Inc","startDate":"2005-07","conditions":"Healthy","enrollment":28},{"nctId":"NCT00648804","phase":"PHASE1","title":"Food Study of Ondansetron Orally Disintegrating Tablets 8 mg to Zofran ODT® Tablets 8 mg","status":"COMPLETED","sponsor":"Mylan Pharmaceuticals Inc","startDate":"2005-07","conditions":"Healthy","enrollment":28},{"nctId":"NCT06371014","phase":"NA","title":"Comparative Study on the Efficacy and Safety of Ondansetron Oral Membrane for the Prevention of Vomiting During Moderate Hypoemetic Chemotherapy","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Children's Medical Center","startDate":"2024-05-01","conditions":"To Analyze and Compare the Efficacy and Safety of Ondansetron and Tablet for the Prevention of Moderate and Hypoemetic Chemotherapy","enrollment":200},{"nctId":"NCT03125811","phase":"EARLY_PHASE1","title":"Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED)","status":"COMPLETED","sponsor":"Texas Tech University Health Sciences Center, El Paso","startDate":"2017-07-17","conditions":"Nausea, Vomiting","enrollment":121},{"nctId":"NCT03785691","phase":"PHASE2","title":"Validating the Effect og Ondansetron and Mirtazapine in Treating Hyperemesis Gravidarum","status":"TERMINATED","sponsor":"Nordsjaellands Hospital","startDate":"2019-03-01","conditions":"Hyperemesis Gravidarum, Nausea Gravidarum, Vomiting of Pregnancy","enrollment":58},{"nctId":"NCT05590936","phase":"NA","title":"Dimenydrinate vs Ondansetron for PONV (DONV)","status":"COMPLETED","sponsor":"University of Thessaly","startDate":"2018-01-01","conditions":"PONV in Laparoscopic Cholocystectomies","enrollment":190},{"nctId":"NCT04232423","phase":"PHASE3","title":"Olanzapine for Chemotherapy-induced Nausea and Vomiting Prophylaxis","status":"COMPLETED","sponsor":"Department of Medical Services Ministry of Public Health of Thailand","startDate":"2020-03-01","conditions":"Complete Response Rate to Chemotherapy-induced Nausea and Vomiting Prophylaxis","enrollment":90},{"nctId":"NCT01220167","phase":"PHASE1","title":"Three-way Crossover Study Comparing Ondansetron ODFS Administered With and Without Water to Zofran ODT Without Water","status":"COMPLETED","sponsor":"Aquestive Therapeutics","startDate":"2008-08","conditions":"Healthy Participants","enrollment":18},{"nctId":"NCT01217190","phase":"PHASE1, PHASE2","title":"Crossover Study Comparing Ondansetron Orally Dissolving Film Strip (ODFS) With Zofran Orally Disintegrating Tablets","status":"COMPLETED","sponsor":"MonoSol Rx","startDate":"2008-09-16","conditions":"Nausea and Vomiting, Postoperative, Nausea With Vomiting Chemotherapy-Induced","enrollment":48},{"nctId":"NCT03833999","phase":"PHASE4","title":"Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea","status":"COMPLETED","sponsor":"University of Nottingham","startDate":"2018-10-16","conditions":"Motility Disorder of Intestine, Ondansetron, Small Bowel Water","enrollment":16},{"nctId":"NCT02246439","phase":"PHASE3","title":"BEKINDA (Ondansetron 24 mg Bimodal Release Tablets) for Vomiting Due to Presumed Acute Gastroenteritis or Gastritis","status":"COMPLETED","sponsor":"RedHill Biopharma Limited","startDate":"2014-12-08","conditions":"Gastroenteritis, Gastritis","enrollment":330},{"nctId":"NCT01549652","phase":"NA","title":"5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence","status":"COMPLETED","sponsor":"Stanford University","startDate":"2011-04","conditions":"Opioid Withdrawal, Physical Dependence","enrollment":133},{"nctId":"NCT03254459","phase":"PHASE2","title":"Study of Buprenorphine Sublingual Spray Versus Standard of Care Narcotic Therapy for the Treatment of Post-Operative Pain","status":"COMPLETED","sponsor":"INSYS Therapeutics Inc","startDate":"2017-09-12","conditions":"Pain, Postoperative","enrollment":100},{"nctId":"NCT02635984","phase":"PHASE3","title":"Study of FOND Versus FOND+O for the Prevention of CINV in Hematology Patients Receiving Highly Emetogenic Chemotherapy Regimens","status":"COMPLETED","sponsor":"Augusta University","startDate":"2015-11","conditions":"Complications of Bone Marrow Transplant, Hematologic Neoplasms","enrollment":108},{"nctId":"NCT00120744","phase":"NA","title":"Oral Disintegrating Ondansetron Tablet to Reduce Vomiting From Gastroenteritis in a Pediatric Emergency Department","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2004-01","conditions":"Gastroenteritis, Vomiting, Diarrhea","enrollment":""},{"nctId":"NCT01870635","phase":"PHASE4","title":"Ondansetron Administration to WELL Children With Gastroenteritis Associated Vomiting in EDs in Pakistan","status":"COMPLETED","sponsor":"Dr. Stephen Freedman","startDate":"2014-05","conditions":"Dehydration, Gastroenteritis, Vomiting","enrollment":625},{"nctId":"NCT01870648","phase":"PHASE4","title":"Ondansetron Administration to Children With Gastroenteritis, Vomiting and SOME Dehydration in EDs in Pakistan","status":"COMPLETED","sponsor":"Dr. Stephen Freedman","startDate":"2014-05","conditions":"Dehydration, Gastroenteritis, Vomiting","enrollment":918},{"nctId":"NCT00437229","phase":"PHASE1","title":"A Study to Assess the Safety & Interaction Between GW679769, Dexamethasone, & Ondansetron When Taken by Healthy Adults","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-02-19","conditions":"Nausea and Vomiting, Chemotherapy-Induced","enrollment":37},{"nctId":"NCT01449188","phase":"PHASE1","title":"To Investigate the Effect of Intravenous Ondansetron on Cardiac Conduction as Compared to Placebo and Moxifloxacin in Healthy Adult Subjects","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2011-08-16","conditions":"Nausea and Vomiting, Chemotherapy-Induced","enrollment":60},{"nctId":"NCT01217801","phase":"PHASE1","title":"Two Way Bioequivalence Study Under Fed Conditions","status":"COMPLETED","sponsor":"MonoSol Rx","startDate":"2008-10","conditions":"Healthy","enrollment":48},{"nctId":"NCT00971633","phase":"PHASE1","title":"A Bioequivalence Study of 3 Formulations of Ondansetron in Healthy Adults (0869-095)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2003-11","conditions":"Chemotherapy-Induced Nausea and Vomiting","enrollment":12},{"nctId":"NCT01953978","phase":"PHASE4","title":"The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2012-12","conditions":"Pain","enrollment":160},{"nctId":"NCT01933542","phase":"PHASE4","title":"The Effect of Chlorzoxazone on Moderate to Severe Postoperative Pain After Spine Surgery","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2013-08","conditions":"Chlorzoxazone, Postoperative Pain","enrollment":110},{"nctId":"NCT01952886","phase":"PHASE2","title":"Patient Satisfaction, Efficacy and Compliance of Antiemetic Patch vs Pill in Malignant Glioma Patients","status":"WITHDRAWN","sponsor":"Duke University","startDate":"","conditions":"Malignant Glioma","enrollment":""},{"nctId":"NCT00080444","phase":"PHASE3","title":"Study of Aprepitant (MK-0869) for Chemotherapy-Induced Nausea and Vomiting (CINV) in Adolescent Participants (MK-0869-097)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2004-04","conditions":"Vomiting","enrollment":50},{"nctId":"NCT02174874","phase":"","title":"Ondansetron Oral Versus Orally Disintegrating Tablets (ODT)","status":"COMPLETED","sponsor":"Dr. Graham Thompson","startDate":"2011-06","conditions":"Acute Gastroenteritis","enrollment":462},{"nctId":"NCT01572012","phase":"PHASE1","title":"Phase 1 Safety, Tolerability and PK Study of Ondansetron and Hylenex Recombinant in Healthy Volunteers","status":"COMPLETED","sponsor":"Halozyme Therapeutics","startDate":"2012-02","conditions":"Healthy","enrollment":12},{"nctId":"NCT00878228","phase":"PHASE4","title":"Antiemetic Prophylaxis for Postdischarge Nausea and Vomiting After Hip Arthroscopy","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2009-04","conditions":"Nausea and Vomiting, Postoperative","enrollment":98},{"nctId":"NCT01275248","phase":"PHASE2","title":"Efficacy and Safety Study of Low-Dose Ondansetron For Adjunctive Therapy In Adult Patients With Obsessive-Compulsive Disorder","status":"TERMINATED","sponsor":"Transcept Pharmaceuticals","startDate":"2011-01","conditions":"Obsessive-compulsive Disorder","enrollment":130},{"nctId":"NCT00366834","phase":"PHASE3","title":"Intravenous And Oral Casopitant (GW679769) For The Prevention Of Chemotherapy Induced Nausea And Vomiting","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-07","conditions":"Vomiting, Nausea, Nausea and Vomiting, Chemotherapy-Induced","enrollment":1840},{"nctId":"NCT01523119","phase":"NA","title":"Bioequivalence Study of Ondansetron Orally Disintegrating Tablets 8mg Under Fed Conditions","status":"COMPLETED","sponsor":"Ranbaxy Laboratories Limited","startDate":"2006-07","conditions":"Healthy","enrollment":35},{"nctId":"NCT01523093","phase":"NA","title":"Bioequivalence Study of Ondansetron Orally Disintegrating Tablets 8mg Under Fasting Conditions","status":"COMPLETED","sponsor":"Ranbaxy Laboratories Limited","startDate":"2006-07","conditions":"Healthy","enrollment":32},{"nctId":"NCT01511718","phase":"PHASE1","title":"Bioequivalence Study for Ondansetron Hydrochloride Tablets 8 mg Under Fed Condition","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2006-10","conditions":"Healthy","enrollment":26},{"nctId":"NCT01511705","phase":"PHASE1","title":"Bioequivalence Study for Ondansetron Hydrochloride Tablets 8 mg Under Fasting Condition","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2006-10","conditions":"Healthy","enrollment":26},{"nctId":"NCT00659074","phase":"PHASE1","title":"Bioavailability Study of Ondansetron 24 mg Orally Disintegrating Tablets Under Fasting Conditions","status":"COMPLETED","sponsor":"Par Pharmaceutical, Inc.","startDate":"2003-10","conditions":"Healthy","enrollment":24},{"nctId":"NCT00659685","phase":"PHASE1","title":"Bioavailability Study of Ondansetron 16 mg Orally Disintegrating Tablets Under Fasting Conditions","status":"COMPLETED","sponsor":"Par Pharmaceutical, Inc.","startDate":"2003-11","conditions":"Healthy","enrollment":24},{"nctId":"NCT00654277","phase":"PHASE1","title":"Bioavailability Study of Ondansetron Orally Disintegrating Tablets Under Fasting Conditions","status":"COMPLETED","sponsor":"Par Pharmaceutical, Inc.","startDate":"2002-08","conditions":"Healthy","enrollment":32},{"nctId":"NCT00653458","phase":"PHASE1","title":"Bioavailability Study of Ondansetron Orally Disintegrating Tablets Under Fed Conditions","status":"COMPLETED","sponsor":"Par Pharmaceutical, Inc.","startDate":"2002-08","conditions":"Healthy","enrollment":18}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dexamethasone intravenous","Casopitant (GW679769) oral tablets","Casopitant (GW679769) intravenous"],"phase":"phase_3","status":"active","brandName":"Ondansetron oral tablets","genericName":"Ondansetron oral tablets","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ondansetron works by blocking serotonin receptors in the body, which helps to reduce nausea and vomiting. Used for Prevention of nausea and vomiting caused by cancer chemotherapy, Prevention of nausea and vomiting caused by radiation therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}