{"id":"ondansetron-intraperitoneal-lavage","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1201111","moleculeType":"Small molecule","molecularWeight":"329.83"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ondansetron is a selective 5-HT3 receptor antagonist that works locally when instilled into the peritoneal cavity during lavage procedures. By blocking serotonin signaling at chemoreceptor trigger zone and vagal afferent pathways, it reduces the emetogenic stimulus associated with peritoneal manipulation and fluid instillation. This local application may provide targeted antiemetic effects with potentially reduced systemic exposure compared to parenteral administration.","oneSentence":"Ondansetron blocks serotonin 5-HT3 receptors in the peritoneal cavity to prevent nausea and vomiting during intraperitoneal lavage procedures.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:58:21.729Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of nausea and vomiting associated with intraperitoneal lavage procedures"}]},"trialDetails":[{"nctId":"NCT06632184","phase":"PHASE4","title":"Peritoneal Lavage Using Saline or Saline With Ondansetron for Pain Control After Laparoscopic Cholecystectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2025-12-01","conditions":"Postoperative Pain Management, Laparoscopic Cholecystectomy, Ondansetron","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ondansetron","Zofran","0.9% Sodium Chloride"],"phase":"marketed","status":"active","brandName":"Ondansetron Intraperitoneal Lavage","genericName":"Ondansetron Intraperitoneal Lavage","companyName":"Instituto Mexicano del Seguro Social","companyId":"instituto-mexicano-del-seguro-social","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ondansetron blocks serotonin 5-HT3 receptors in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting. Used for Prevention of postoperative nausea and vomiting (PONV) following abdominal surgery via intraperitoneal administration.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}