{"id":"onabotulinumtoxina-ona","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Injection site pain or bruising"},{"rate":"1-5","effect":"Facial weakness or drooping"},{"rate":"1-3","effect":"Eyelid ptosis"},{"rate":"1-3","effect":"Brow ptosis"},{"rate":"1-5","effect":"Flu-like symptoms"},{"rate":"5-10","effect":"Neck pain"}]},"_chembl":{"chemblId":"CHEMBL1201574","moleculeType":"Unknown"},"_dailymed":{"setId":"a6f42753-d31e-4b23-8da0-4b990fee4b38","title":"BOTOX (ONABOTULINUMTOXINA) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [SPORTPHARM LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"OnabotulinumtoxinA is a botulinum toxin serotype A that cleaves SNARE proteins required for acetylcholine vesicle release. By preventing neurotransmitter release at the neuromuscular junction, it causes temporary paralysis of targeted muscles. This effect is used cosmetically to reduce facial wrinkles caused by muscle contraction and therapeutically to treat conditions involving muscle hyperactivity.","oneSentence":"OnabotulinumtoxinA blocks acetylcholine release at the neuromuscular junction, paralyzing muscles and reducing dynamic wrinkles and muscle contractions.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:50.042Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Facial wrinkles and dynamic expression lines (cosmetic)"},{"name":"Cervical dystonia"},{"name":"Chronic migraine"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Hyperhidrosis"},{"name":"Spasticity"}]},"trialDetails":[{"nctId":"NCT06782464","phase":"NA","title":"Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment","status":"RECRUITING","sponsor":"Centre National de Rééducation Fonctionnelle et de Réadaptation","startDate":"2024-12-12","conditions":"Hemiplegia, Spasticity, Shoulder Spasticity","enrollment":50},{"nctId":"NCT06886750","phase":"PHASE4","title":"The Effects of Waning of Botulinum Toxin in the Treatment of Cervical Dystonia","status":"NOT_YET_RECRUITING","sponsor":"Western University, Canada","startDate":"2025-03-30","conditions":"Cervical Dystonia, Primary","enrollment":45},{"nctId":"NCT04756882","phase":"PHASE2, PHASE3","title":"Clinical Evaluation of the Efficacy OF Botulinum Toxin A for Improving Facial Scars","status":"UNKNOWN","sponsor":"Alexandria University","startDate":"2020-11-18","conditions":"Hypertrophic Scarring","enrollment":12},{"nctId":"NCT01732809","phase":"PHASE4","title":"Fields Of Effects Of Two Commercial Preparations Of Botulinum Toxin Type A At Equal Labeled Unit Doses","status":"COMPLETED","sponsor":"Hexsel Dermatology Clinic","startDate":"2011-01","conditions":"Skin Wrinkling","enrollment":19},{"nctId":"NCT01930604","phase":"PHASE2","title":"Botulinum Toxin Treatment in Craniofacial, Inguinal, Palmar, Plantar and Truncal Hyperhidrosis","status":"UNKNOWN","sponsor":"Carl Swartling","startDate":"2013-09","conditions":"Hyperhidrosis","enrollment":588}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":57,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Botox®"],"phase":"marketed","status":"active","brandName":"OnabotulinumtoxinA (ONA)","genericName":"OnabotulinumtoxinA (ONA)","companyName":"Hexsel Dermatology Clinic","companyId":"hexsel-dermatology-clinic","modality":"Small molecule","firstApprovalDate":"","aiSummary":"OnabotulinumtoxinA blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Facial wrinkles and dynamic expression lines (cosmetic), Cervical dystonia, Chronic migraine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}