{"id":"onabotulinumtoxina-145-unt-botox","safety":{"commonSideEffects":[{"rate":"7–13%","effect":"Headache"},{"rate":"10–16%","effect":"Neck pain"},{"rate":"1–3%","effect":"Injection site pain"},{"rate":"1–5%","effect":"Muscle weakness"},{"rate":"1–3%","effect":"Eyelid ptosis"},{"rate":"1–2%","effect":"Diplopia"},{"rate":"1–2%","effect":"Dry mouth"}]},"_chembl":{"chemblId":"CHEMBL1201574","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug is a botulinum toxin serotype A that irreversibly cleaves SNAP-25, a protein essential for acetylcholine vesicle release. This prevents neurotransmitter signaling at the neuromuscular junction, resulting in flaccid paralysis of targeted muscles. The effect is temporary, lasting 3–4 months, after which nerve terminals regenerate and muscle function returns.","oneSentence":"OnabotulinumtoxinA blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:17.657Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Chronic migraine"},{"name":"Severe primary axillary hyperhidrosis"},{"name":"Glabellar lines (aesthetic use)"},{"name":"Crow's feet (aesthetic use)"},{"name":"Forehead lines (aesthetic use)"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["BOTOX"],"phase":"marketed","status":"active","brandName":"OnabotulinumtoxinA 145 UNT [Botox]","genericName":"OnabotulinumtoxinA 145 UNT [Botox]","companyName":"Beth Israel Deaconess Medical Center","companyId":"beth-israel-deaconess-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"OnabotulinumtoxinA blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Strabismus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}