{"id":"onabotulinumtoxin-a-bont","safety":{"commonSideEffects":[{"rate":"5–15%","effect":"Headache"},{"rate":"10–20%","effect":"Neck pain"},{"rate":"5–10%","effect":"Injection site pain"},{"rate":"5–15%","effect":"Muscle weakness"},{"rate":"1–5%","effect":"Eyelid ptosis"},{"rate":"1–5%","effect":"Dry mouth"},{"rate":"1–3%","effect":"Flu-like symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The toxin is a zinc-dependent endopeptidase that cleaves SNAP-25, a protein essential for acetylcholine vesicle fusion and release. This prevents neurotransmitter signaling at the neuromuscular junction, resulting in flaccid paralysis of injected muscles. The effect is temporary, lasting 3–4 months, after which nerve terminals regenerate and function is restored.","oneSentence":"Onabotulinumtoxin A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:21.791Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Chronic migraine"},{"name":"Overactive bladder"},{"name":"Hyperhidrosis"},{"name":"Glabellar lines and facial wrinkles (cosmetic)"}]},"trialDetails":[{"nctId":"NCT07398755","phase":"","title":"Prospective, Non-interventional Study Assessing Periorbital Rejuvenation Procedure","status":"COMPLETED","sponsor":"Yuvell","startDate":"2025-09-02","conditions":"Glabellar Lines, Midface Volume Deficiency, Periorbital Wrinkling","enrollment":29},{"nctId":"NCT06782464","phase":"NA","title":"Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment","status":"RECRUITING","sponsor":"Centre National de Rééducation Fonctionnelle et de Réadaptation","startDate":"2024-12-12","conditions":"Hemiplegia, Spasticity, Shoulder Spasticity","enrollment":50},{"nctId":"NCT07426640","phase":"NA","title":"Dual-Site Botulinum Toxin Type A Injection for Lifelong Premature Ejaculation","status":"COMPLETED","sponsor":"Al Mouwasat Hospital","startDate":"2021-11-01","conditions":"Premature (Early) Ejaculation","enrollment":150},{"nctId":"NCT07440173","phase":"PHASE4","title":"Phenol and Botulinum Toxin vs Botulinum Toxin Alone for Post-Stroke Upper-Limb Spasticity","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-05-01","conditions":"Spasticity as Sequela of Stroke","enrollment":60},{"nctId":"NCT07233993","phase":"NA","title":"UltraSound-Guided Versus Non-Ultrasound-Guided Botulinum Toxin Injections in Cervical Dystonia [CUSTODY]","status":"RECRUITING","sponsor":"Fondazione I.R.C.C.S. 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