{"id":"onabotulinum-toxin-a","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Headache"},{"rate":"10-20","effect":"Neck pain"},{"rate":"5-10","effect":"Injection site pain"},{"rate":"5-15","effect":"Muscle weakness"},{"rate":"1-5","effect":"Eyelid ptosis"},{"rate":"1-5","effect":"Dry mouth"},{"rate":"1-3","effect":"Flu-like symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The toxin is a zinc-dependent endopeptidase that cleaves SNAP-25, a protein essential for acetylcholine vesicle fusion and release. This prevents neuromuscular transmission, resulting in flaccid paralysis of injected muscles. The effect is temporary, lasting 3-4 months, after which nerve terminals regenerate and muscle function returns.","oneSentence":"Onabotulinum toxin A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:35:21.677Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Chronic migraine"},{"name":"Hyperhidrosis"},{"name":"Spasticity"},{"name":"Cosmetic wrinkles (glabellar lines, crow's feet)"}]},"trialDetails":[{"nctId":"NCT06840730","phase":"NA","title":"Efficiency of Botulinum Toxin type-a in the Management of the Myofascial Pain","status":"COMPLETED","sponsor":"Hacettepe University","startDate":"2024-06-03","conditions":"Myofascial Pain - Dysfunction Syndrome of TMJ","enrollment":25},{"nctId":"NCT06928246","phase":"PHASE1","title":"The Impact of Botox on 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Used for Cervical dystonia, Blepharospasm, Strabismus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}