{"id":"omez-40","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Diarrhea"},{"rate":"2-5","effect":"Nausea"},{"rate":"2-5","effect":"Abdominal pain"},{"rate":"2-5","effect":"Constipation"}]},"_chembl":{"chemblId":"CHEMBL3656159","moleculeType":"Small molecule","molecularWeight":"406.49"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Omeprazole is a proton pump inhibitor (PPI) that irreversibly binds to and inactivates the H+/K+-ATPase enzyme in the gastric mucosa. This blocks the final step of gastric acid production, significantly reducing intragastric acidity. It is used to treat acid-related disorders by maintaining elevated gastric pH.","oneSentence":"Omeprazole inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:53.123Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"},{"name":"Zollinger-Ellison syndrome"},{"name":"Prevention of NSAID-induced ulcers"}]},"trialDetails":[{"nctId":"NCT05680870","phase":"PHASE3","title":"The Possible Protective Role of Omeprazole Against Oxaliplatin Induced Neuropathy in Cancer Patients","status":"COMPLETED","sponsor":"Aya Mohamed Sadek Elsaid","startDate":"2023-02-01","conditions":"Chemotherapy Induced Peripheral Neuropathy","enrollment":46},{"nctId":"NCT02922699","phase":"PHASE4","title":"Efficacy and Saafety of Omez Iin Patients With H.Pylori Associated Diseases","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2013-01","conditions":"GERD","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["OMEPRAZOLE 40MG"],"phase":"marketed","status":"active","brandName":"OMEZ 40","genericName":"OMEZ 40","companyName":"Dr. Reddy's Laboratories Limited","companyId":"dr-reddy-s-laboratories-limited","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Omeprazole inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion. Used for Gastroesophageal reflux disease (GERD), Peptic ulcer disease, Zollinger-Ellison syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}