{"id":"omeprezole-losec","safety":{"commonSideEffects":[{"rate":"7","effect":"Headache"},{"rate":"3","effect":"Diarrhea"},{"rate":"2","effect":"Abdominal pain"},{"rate":"2","effect":"Nausea"},{"rate":null,"effect":"Hypomagnesemia (with long-term use)"},{"rate":null,"effect":"Vitamin B12 deficiency (with long-term use)"}]},"_chembl":{"chemblId":"CHEMBL2105294","moleculeType":"Small molecule","molecularWeight":"367.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Omeprazole is a proton pump inhibitor (PPI) that binds to and inactivates the H+/K+-ATPase enzyme on the secretory surface of gastric parietal cells. This blocks the final step of gastric acid production, significantly reducing both basal and stimulated acid secretion. It is used to treat acid-related disorders by maintaining elevated gastric pH.","oneSentence":"Omeprazole irreversibly inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:14.494Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"},{"name":"Zollinger-Ellison syndrome"},{"name":"Prevention of NSAID-induced ulcers"}]},"trialDetails":[{"nctId":"NCT00825630","phase":"PHASE4","title":"13-C Urea Breath Test Using BreathID System and PPIs (Proton Pump Inhibitors)","status":"COMPLETED","sponsor":"Meridian Bioscience, Inc.","startDate":"2008-11","conditions":"Helicobacter Pylori Infection","enrollment":123}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Losec"],"phase":"marketed","status":"active","brandName":"Omeprezole (Losec)","genericName":"Omeprezole (Losec)","companyName":"Meridian Bioscience, Inc.","companyId":"meridian-bioscience-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Omeprazole inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion. Used for Gastroesophageal reflux disease (GERD), Peptic ulcer disease, Zollinger-Ellison syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}