{"id":"omeprazole-domperidone-sr","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Omeprazole is a proton pump inhibitor that suppresses acid production by blocking H+/K+-ATPase in gastric parietal cells. Domperidone is a dopamine antagonist that increases gastric contractions and accelerates food movement through the stomach. The sustained-release formulation provides prolonged therapeutic effect, making this combination useful for acid-related disorders with concurrent gastric dysmotility.","oneSentence":"Omeprazole reduces gastric acid secretion while domperidone enhances gastric motility and accelerates gastric emptying.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:58:16.787Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD) with gastric dysmotility"},{"name":"Peptic ulcer disease with impaired gastric emptying"},{"name":"Functional dyspepsia with acid hypersecretion"}]},"trialDetails":[{"nctId":"NCT02140073","phase":"PHASE4","title":"Research of Efficient Use of Omeprazole in Combination With Domperidone in Gastroesophageal Reflux Disease of Mild to Moderate Severity","status":"UNKNOWN","sponsor":"Belarusian Medical Academy of Post-Graduate Education","startDate":"2013-12","conditions":"GERD","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Omez DSR"],"phase":"marketed","status":"active","brandName":"omeprazole+domperidone SR","genericName":"omeprazole+domperidone SR","companyName":"Belarusian Medical Academy of Post-Graduate Education","companyId":"belarusian-medical-academy-of-post-graduate-education","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Omeprazole reduces gastric acid secretion while domperidone enhances gastric motility and accelerates gastric emptying. Used for Gastroesophageal reflux disease (GERD) with gastric dysmotility, Peptic ulcer disease with impaired gastric emptying, Functional dyspepsia with acid hypersecretion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}