{"id":"omeprazole-amoxicillin-metronidazole-and-clarithromycin","safety":{"commonSideEffects":[{"rate":"15-30","effect":"Diarrhea"},{"rate":"10-20","effect":"Nausea"},{"rate":"5-15","effect":"Abdominal pain"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Taste disturbance (metallic taste from metronidazole)"},{"rate":"1-3","effect":"Allergic reactions (amoxicillin)"}]},"_chembl":{"chemblId":"CHEMBL2105950","moleculeType":"Small molecule","molecularWeight":"387.39"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Omeprazole is a proton pump inhibitor that reduces gastric acid secretion, creating an environment where the three antibiotics—amoxicillin, metronidazole, and clarithromycin—can effectively penetrate and kill H. pylori. Amoxicillin and clarithromycin inhibit bacterial protein synthesis and cell wall formation, while metronidazole generates reactive oxygen species that damage bacterial DNA. This multi-pronged approach significantly increases eradication rates compared to dual or triple therapy.","oneSentence":"This is a quadruple therapy combination that eradicates Helicobacter pylori by suppressing gastric acid while simultaneously attacking the bacteria with three different antibiotics.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:20.055Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Helicobacter pylori infection eradication in peptic ulcer disease"},{"name":"H. pylori-associated chronic gastritis"}]},"trialDetails":[{"nctId":"NCT07312721","phase":"PHASE4","title":"Comparative Effectiveness of Triple Versus Quadruple Therapy in the Treatment of Helicobacter Pylori Induced Gastritis","status":"COMPLETED","sponsor":"Azfar Farogh","startDate":"2024-01-05","conditions":"Helicobacter Pylori Infection, Chronic Gastritis, Peptic Ulcer Disease","enrollment":752},{"nctId":"NCT07104318","phase":"PHASE3","title":"Personalized vs Standard of Care Treatment for Helicobacter Pylori Eradication Among Veterans","status":"NOT_YET_RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2026-04-01","conditions":"Helicobacter Pylori","enrollment":360},{"nctId":"NCT07021729","phase":"PHASE4","title":"Comparison of Two Treatment Regimens of Helicobacter Pylori Infection","status":"NOT_YET_RECRUITING","sponsor":"Rehman Medical Institute - RMI","startDate":"2025-12","conditions":"Helicobacter Pylori Infection","enrollment":156},{"nctId":"NCT03365609","phase":"NA","title":"A Comparison of Four Different Treatment Regimens of Helicobacter Pylori in Chinese Children","status":"RECRUITING","sponsor":"Ying HUANG","startDate":"2017-09-20","conditions":"Helicobacter Infections","enrollment":1440},{"nctId":"NCT05664685","phase":"PHASE4","title":"Optimized Bismuth Quadruple Therapy vs Triple Standard Therapy for Helicobacter Pylori Eradication","status":"COMPLETED","sponsor":"Pontificia Universidad Catolica de Chile","startDate":"2022-10-17","conditions":"Helicobacter Pylori Infection","enrollment":127},{"nctId":"NCT06315478","phase":"PHASE4","title":"Safety and Efficacy of Triple and Quadruple Regimens as First Line Therapy for Management of Helicobacter Pylori Infection in Egyptians","status":"COMPLETED","sponsor":"Helwan University","startDate":"2021-02-01","conditions":"H.Pylori Infection","enrollment":60},{"nctId":"NCT06216639","phase":"","title":"Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection","status":"UNKNOWN","sponsor":"National Institute of Public Health, Slovenia","startDate":"2024-02-01","conditions":"Helicobacter Pylori Infection","enrollment":2000},{"nctId":"NCT02373280","phase":"NA","title":"The Efficacy of the 7 Days Tailored Therapy as the 1st Eradication of H. Pylori Infection","status":"UNKNOWN","sponsor":"Seoul National University Bundang Hospital","startDate":"2014-08","conditions":"Helicobacter Infection","enrollment":600},{"nctId":"NCT04660123","phase":"PHASE4","title":"A Real World Study of Bismuth Colloidal Pectin Granules Quadruple Therapy for H. Pylori Eradication","status":"COMPLETED","sponsor":"Xijing Hospital of Digestive Diseases","startDate":"2020-12-20","conditions":"Gastric Cancer, Helicobacter Pylori Infection, Bismuth","enrollment":959},{"nctId":"NCT04178187","phase":"NA","title":"The Role of Probiotics in the Eradication of Helicobacter Pylori","status":"COMPLETED","sponsor":"Evangelismos Hospital","startDate":"2019-10-02","conditions":"Helicobacter Pylori Infection","enrollment":660},{"nctId":"NCT05250050","phase":"PHASE4","title":"Susceptibility-Guided Therapy for Helicobacter Pylori Infection Treatment","status":"UNKNOWN","sponsor":"Shanghai Zhongshan Hospital","startDate":"2022-03-25","conditions":"Helicobacter Pylori Infection","enrollment":388},{"nctId":"NCT03592069","phase":"PHASE4","title":"Concomitant Versus Hybrid Regimen for H. Pylori Eradication","status":"COMPLETED","sponsor":"Alexandra Hospital, Athens, Greece","startDate":"2018-02-21","conditions":"H.Pylori Infection, H.Pylori Gastrointestinal Disease, H. Pylori Associated Phlegmonous Gastritis","enrollment":345},{"nctId":"NCT04721704","phase":"NA","title":"Comparison of Efficacy of Triple Regimen Based on Clarithromycin VS Metronidazole in Children","status":"UNKNOWN","sponsor":"Shaheed Zulfiqar Ali Bhutto Medical University","startDate":"2020-09-14","conditions":"H Pylori Gastritis","enrollment":36},{"nctId":"NCT04617613","phase":"PHASE4","title":"Comparing Different Regimens for Eradication of Helicobacter Pylori in Kuwait","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2016-09","conditions":"Helicobacter Pylori Infection","enrollment":603},{"nctId":"NCT04445948","phase":"PHASE4","title":"Lactoferrin in Helicobacter Pylori Eradication Either With Standard Triple Therapy or Sequential Therapy","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2019-11-30","conditions":"Helicobacter Pylori Infection","enrollment":400},{"nctId":"NCT04359966","phase":"NA","title":"Prospective Randomised Trial of First and Second Line Treatments of RCT of First and Second Line H Pylori Treatments in Slovenia","status":"UNKNOWN","sponsor":"Slovenian Society for Gastroenterology and Hepatology","startDate":"2020-05-10","conditions":"Helicobacter Pylori Infection, Eradication Treatments","enrollment":560},{"nctId":"NCT04039412","phase":"PHASE4","title":"Comparison Between Quadruple Regimens for Helicobacter Pylori Infection in Egypt","status":"COMPLETED","sponsor":"Ayman Magd Eldin Mohammad Sadek","startDate":"2018-06-01","conditions":"Helicobacter Pylori Infection","enrollment":330},{"nctId":"NCT04090021","phase":"PHASE4","title":"Genotypic Resistance-guided Versus Empirical Therapy for H. Pylori Eradication.","status":"UNKNOWN","sponsor":"Konstantopoulio-Patission General Hospital of Nea Ionia","startDate":"2019-09-01","conditions":"Helicobacter Pylori Infection","enrollment":304},{"nctId":"NCT03383003","phase":"NA","title":"Comparison of Two Novel First-line Anti-Helicobacter Pylori Therapy","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2016-03-01","conditions":"Helicobacter Pylori Infection","enrollment":240},{"nctId":"NCT00002682","phase":"PHASE2","title":"Antibiotic Therapy and Antacids in Patients With Malt Lymphoma of the Stomach","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"1995-08-10","conditions":"Lymphoma","enrollment":5},{"nctId":"NCT02894268","phase":"PHASE4","title":"Doxycycline- and Furazolidone-containing Quadruple Regimen is Superior of Tailored Therapy","status":"UNKNOWN","sponsor":"Sir Run Run Shaw Hospital","startDate":"2016-02","conditions":"Helicobacter Pylori Infection","enrollment":300},{"nctId":"NCT02935010","phase":"PHASE4","title":"Tailored Versus Empiric Therapy for Helicobacter Pylori Treatment","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2017-02-05","conditions":"Helicobacter Pylori Infection","enrollment":382},{"nctId":"NCT03413020","phase":"PHASE4","title":"Tailored Therapy for Helicobacter Pylori Rescue Treatment","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2018-01-03","conditions":"Helicobacter Pylori Infection","enrollment":200},{"nctId":"NCT02732249","phase":"PHASE4","title":"Clarithromycin Triple Therapy Plus Bismuth for Helicobacter Pylori First-line Treatment","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2016-04-01","conditions":"Helicobacter Pylori Infection","enrollment":66},{"nctId":"NCT03555526","phase":"PHASE4","title":"Genotypic Resistance Guided Therapy for Refractory H. Pylori Infection","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2017-12-15","conditions":"H Pylori Infection","enrollment":320},{"nctId":"NCT03208426","phase":"PHASE4","title":"Sequential Versus Quadruple Therapy in the Second-line Treatment","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2017-10-01","conditions":"Helicobacter Pylori Infection","enrollment":240},{"nctId":"NCT02959255","phase":"PHASE4","title":"10-day Versus 14-day Concomitant PAMC as First-line Treatment Strategy for the Eradication of H. Pylori Infection","status":"COMPLETED","sponsor":"Elpen Pharmaceutical Co. Inc.","startDate":"2017-01-30","conditions":"Helicobacter Pylori Infection","enrollment":364},{"nctId":"NCT00669955","phase":"PHASE3","title":"Efficacy and Safety of Quadruple Therapy in Eradication of H. Pylori: A Comparison to Triple Therapy","status":"COMPLETED","sponsor":"Forest Laboratories","startDate":"2008-06","conditions":"Helicobacter Infections","enrollment":440},{"nctId":"NCT02689583","phase":"NA","title":"A Multi-center Study for Individual Treatment of Helicobacter Pylori Infection","status":"UNKNOWN","sponsor":"First Affiliated Hospital of Zhejiang University","startDate":"2016-03","conditions":"Gastritis, Gastric Ulcer","enrollment":3000},{"nctId":"NCT02635191","phase":"PHASE4","title":"Tailored Therapy for Helicobacter Pylori in Children","status":"UNKNOWN","sponsor":"Beijing Children's Hospital","startDate":"2014-03","conditions":"Helicobacter Pylori Infection","enrollment":200},{"nctId":"NCT00656968","phase":"PHASE4","title":"Comparison of Sequential or Concomitant Therapy for Helicobacter Pylori Infection","status":"COMPLETED","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2007-05","conditions":"Helicobacter Infection","enrollment":232},{"nctId":"NCT01085786","phase":"PHASE4","title":"Sequential and Hybrid Therapies for H Pylori Infection","status":"COMPLETED","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2008-08","conditions":"Helicobacter Pylori Infection","enrollment":240},{"nctId":"NCT00475527","phase":"PHASE4","title":"Helicobacter Pylori and Iron Deficiency: Prevalence of Association and Effect of Therapy","status":"WITHDRAWN","sponsor":"Hadassah Medical Organization","startDate":"","conditions":"Anemia, Iron-Deficiency, Helicobacter Pylori","enrollment":""},{"nctId":"NCT02395458","phase":"PHASE4","title":"Efficacy on Helicobacter Pylori Eradication With Two Antibiotic Regimens","status":"COMPLETED","sponsor":"Coordinación de Investigación en Salud, Mexico","startDate":"2013-03","conditions":"Helicobacter Infections","enrollment":142},{"nctId":"NCT01887249","phase":"PHASE4","title":"15-day Sequential Therapy for Helicobacter Pylori Infection in Korea","status":"COMPLETED","sponsor":"Seoul National University Bundang Hospital","startDate":"2010-05","conditions":"Helicobacter Pylori Infection","enrollment":287},{"nctId":"NCT01760824","phase":"NA","title":"Quadruple Versus Sequential Therapy for Helicobacter Pylori Eradication","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2011-05","conditions":"Helicobacter Pylori Infection","enrollment":391},{"nctId":"NCT01464060","phase":"PHASE4","title":"14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication","status":"UNKNOWN","sponsor":"Infante, Javier Molina, M.D.","startDate":"2011-09","conditions":"Helicobacter Pylori Infection","enrollment":400},{"nctId":"NCT01723059","phase":"NA","title":"Standard Triple Therapy vs Sequential Therapy in Treatment of H Pylori Infection","status":"UNKNOWN","sponsor":"Dallas VA Medical Center","startDate":"2012-02","conditions":"Helicobacter Infection","enrollment":184},{"nctId":"NCT00719420","phase":"PHASE3","title":"Clarithromycin, Amoxicillin, and Metronidazole Based Regimens to Treat Helicobacter Pylori Infections in Colombia","status":"COMPLETED","sponsor":"University of North Texas Health Science Center","startDate":"2006-04","conditions":"Helicobacter Pylori Infection","enrollment":151}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":35,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Quadruple therapy group"],"phase":"marketed","status":"active","brandName":"Omeprazole, Amoxicillin, Metronidazole and Clarithromycin","genericName":"Omeprazole, Amoxicillin, Metronidazole and Clarithromycin","companyName":"Al-Azhar University","companyId":"al-azhar-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a quadruple therapy combination that eradicates Helicobacter pylori by suppressing gastric acid while simultaneously attacking the bacteria with three different antibiotics. Used for Helicobacter pylori infection eradication in peptic ulcer disease, H. pylori-associated chronic gastritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}