{"id":"omapatrilat","rwe":[],"tags":[{"label":"omapatrilat","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Angiotensin-converting enzyme","category":"target"},{"label":"ACE","category":"gene"},{"label":"MME","category":"gene"},{"label":"APP","category":"gene"},{"label":"Active","category":"status"},{"label":"Angiotensin-Converting Enzyme Inhibitors","category":"pharmacology"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Protease Inhibitors","category":"pharmacology"},{"label":"Vasopeptidase Inhibitors","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["BMS-186716","omapatrilat"],"offLabel":[],"synonyms":["BMS-186716","omapatrilat"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"target":"Angiotensin-converting enzyme, Neprilysin, Amyloid beta A4 protein","targets":[{"gene":"ACE","source":"DrugCentral","target":"Angiotensin-converting enzyme","protein":"Angiotensin-converting enzyme"},{"gene":"MME","source":"DrugCentral","target":"Neprilysin","protein":"Neprilysin"},{"gene":"APP","source":"DrugCentral","target":"Amyloid beta A4 protein","protein":"Amyloid beta A4 protein"}],"modality":"Small Molecule","drugClass":"omapatrilat","explanation":"Think of the RAAS system like a water pipe. ACE is like a valve that controls the flow of water, and neprilysin is like a pipe that helps remove excess water. By blocking these two components, omapatrilat helps reduce the amount of water in the body, which can lower blood pressure and improve heart function.","oneSentence":"Omapatrilat works by blocking two enzymes, ACE and neprilysin, to lower blood pressure and improve heart function.","technicalDetail":"Omapatrilat is a dual inhibitor of ACE and neprilysin, with a mechanism of action that involves the inhibition of angiotensin-converting enzyme and neutral endopeptidase, leading to decreased levels of angiotensin II and bradykinin, and increased levels of natriuretic peptides."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1989","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=OMAPATRILAT","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:10:19.911661","biosimilars":[],"competitors":[{"drugName":"alacepril","drugSlug":"alacepril","fdaApproval":"1981-04-06","relationship":"same-target"},{"drugName":"benazepril","drugSlug":"benazepril","fdaApproval":"1991-06-25","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"captopril","drugSlug":"captopril","fdaApproval":"1981-04-06","genericCount":21,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"edetic acid","drugSlug":"edetic-acid","fdaApproval":"1953-07-16","relationship":"same-target"},{"drugName":"enalapril","drugSlug":"enalapril","fdaApproval":"1985-12-24","patentExpiry":"Nov 6, 2032","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"enalaprilat","drugSlug":"enalaprilat","fdaApproval":"1988-02-09","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"fosinopril","drugSlug":"fosinopril","fdaApproval":"1991-05-16","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"lisinopril","drugSlug":"lisinopril","fdaApproval":"1987-12-29","patentExpiry":"Nov 6, 2035","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"losartan","drugSlug":"losartan","fdaApproval":"1995-04-14","patentExpiry":"Oct 7, 2041","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"moexipril","drugSlug":"moexipril","fdaApproval":"1995-04-19","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"omapatrilat","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"alacepril","brandName":"alacepril","genericName":"alacepril","approvalYear":"1981","relationship":"same-target"},{"drugId":"benazepril","brandName":"benazepril","genericName":"benazepril","approvalYear":"1991","relationship":"same-target"},{"drugId":"captopril","brandName":"captopril","genericName":"captopril","approvalYear":"1981","relationship":"same-target"},{"drugId":"edetic-acid","brandName":"edetic acid","genericName":"edetic acid","approvalYear":"1953","relationship":"same-target"},{"drugId":"enalapril","brandName":"enalapril","genericName":"enalapril","approvalYear":"1985","relationship":"same-target"},{"drugId":"enalaprilat","brandName":"enalaprilat","genericName":"enalaprilat","approvalYear":"1988","relationship":"same-target"},{"drugId":"fosinopril","brandName":"fosinopril","genericName":"fosinopril","approvalYear":"1991","relationship":"same-target"},{"drugId":"lisinopril","brandName":"lisinopril","genericName":"lisinopril","approvalYear":"1987","relationship":"same-target"},{"drugId":"losartan","brandName":"losartan","genericName":"losartan","approvalYear":"1995","relationship":"same-target"},{"drugId":"moexipril","brandName":"moexipril","genericName":"moexipril","approvalYear":"1995","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"36NLI90E7T","CHEBI":"CHEBI:135660","VANDF":"4025254","INN_ID":"7714","UMLSCUI":"C0663645","ChEMBL_ID":"CHEMBL289556","KEGG_DRUG":"D01970","DRUGBANK_ID":"DB00886","PDB_CHEM_ID":" FT8","PUBCHEM_CID":"656629","MESH_SUPPLEMENTAL_RECORD_UI":"C106266"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":233,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"OMAPATRILAT","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Omapatrilat is a small molecule. It has multiple synonyms, including BMS-186716 and OMAPATRILATE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}