{"id":"olmesartan-amlodipin","safety":{"commonSideEffects":[{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Hyperkalemia"}]},"_chembl":{"chemblId":"CHEMBL1200692","moleculeType":"Small molecule","molecularWeight":"558.60"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a fixed-dose combination of an angiotensin II receptor blocker (ARB) and a dihydropyridine calcium channel blocker (CCB). Olmesartan prevents angiotensin II from binding to AT1 receptors, reducing vasoconstriction and aldosterone secretion. Amlodipine inhibits L-type calcium channels in vascular smooth muscle and cardiac tissue, causing vasodilation and reduced contractility. Together, they provide complementary antihypertensive effects.","oneSentence":"Olmesartan blocks angiotensin II receptors to lower blood pressure, while amlodipine blocks calcium channels to relax blood vessels and reduce cardiac workload.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:24:00.130Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT01613209","phase":"PHASE3","title":"Sevicontrol-1: Efficacy and Safety of a Fixed Combination of Olmesartan/ Amlodipine","status":"COMPLETED","sponsor":"Institut für Pharmakologie und Präventive Medizin","startDate":"2011-12","conditions":"Hypertension","enrollment":83}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sevikar(r)"],"phase":"phase_3","status":"active","brandName":"Olmesartan/Amlodipin","genericName":"Olmesartan/Amlodipin","companyName":"Institut für Pharmakologie und Präventive Medizin","companyId":"institut-f-r-pharmakologie-und-pr-ventive-medizin","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Olmesartan blocks angiotensin II receptors to lower blood pressure, while amlodipine blocks calcium channels to relax blood vessels and reduce cardiac workload. Used for Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}