{"id":"octodrine","rwe":[{"pmid":"39401652","year":"2025","title":"Heptaminol hair testing to highlight octodrine contamination in supplements, responsible for a doping adverse analytical finding.","finding":"","journal":"Clinica chimica acta; international journal of clinical chemistry","studyType":"Clinical Study"},{"pmid":"38668840","year":"2024","title":"Synthesis and Analysis of Euphorbia cognata Boiss-Assisted Organic-Inorganic Complex: Photosynthesis and Stabilization of CoO Nanoparticles.","finding":"","journal":"Applied biochemistry and biotechnology","studyType":"Clinical Study"},{"pmid":"38246007","year":"2024","title":"Application of a bar adsorptive microextraction based methodology for doping control of alkylamine stimulants in urine matrices.","finding":"","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","studyType":"Clinical Study"},{"pmid":"37357012","year":"2023","title":"Unauthorized ingredients in \"nootropic\" dietary supplements: A review of the history, pharmacology, prevalence, international regulations, and potential as doping agents.","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"},{"pmid":"36569486","year":"2022","title":"Uncovering cloves: characterization of volatile compounds present in clove cigarettes.","finding":"","journal":"Toxicology research","studyType":"Clinical Study"}],"tags":[{"label":"octodrine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"contraindications":["Acute cerebrovascular insufficiency","Acute nephropathy","Alcoholism","Disease of liver","Glaucoma","Hepatic failure","Hypertensive disorder","Organic Cardiac Disease","Peripheral vascular disease","Poisoning by acetaminophen"]},"trials":["NCT03487562","NCT00465049"],"aliases":[],"patents":[],"pricing":[],"allNames":"amidrine","offLabel":[],"synonyms":["octodrine","amidrine","isoctaminum","octodrin","vaporpac"],"timeline":[],"approvals":[],"brandName":"Amidrine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"octodrine","explanation":"Imagine your brain as a computer - Amidrine is thought to be like a software update that helps increase alertness and focus by enhancing the communication between different parts of the brain. This can lead to improved mental clarity and a sense of energy, but more research is needed to confirm its effects and potential side effects.","oneSentence":"Amidrine is believed to work by stimulating the central nervous system.","technicalDetail":"The exact mechanism of action of Amidrine is unknown, but it is believed to interact with various neurotransmitter systems, including dopamine, norepinephrine, and acetylcholine, to produce its effects."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Amidrine","title":"Amidrine","extract":"Amidrine, Midrin, Nodolor, Duradrin, IDA, Migquin, Migrin-A, Migrazone or Epidrine is a combination drug consisting of paracetamol, dichloralphenazone and isometheptene used to treat migraines and severe, refractory headaches."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1978","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=OCTODRINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Amidrine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T15:07:04.774435","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"octodrine","indications":{"approved":[],"offLabel":[{"name":"Migraine","source":"DrugCentral","drugName":"OCTODRINE","evidenceCount":0,"evidenceLevel":"emerging"},{"name":"Tension-type headache","source":"DrugCentral","drugName":"OCTODRINE"},{"name":"Vascular headache","source":"DrugCentral","drugName":"OCTODRINE","evidenceCount":0,"evidenceLevel":"emerging"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT03487562","phase":"Phase 1","title":"A Randomized, Open-label, Multiple Dose, Two-part Phase I Clinical Trial to Compare the Pharmacokinetics, Pharmacodynamics and Safety/Tolerability of DWP14012 After Administrations of DWP14012 Alone a","status":"COMPLETED","sponsor":"Daewoong Pharmaceutical Co. LTD.","isPivotal":false,"enrollment":48,"indication":"Healthy","completionDate":"2019-01-11"},{"nctId":"NCT00465049","phase":"Phase 2","title":"Primary vs. Secondary Closure of Cutaneous Abscesses After I&D: A RCT","status":"COMPLETED","sponsor":"Stony Brook University","isPivotal":false,"enrollment":100,"indication":"Cutanoeus Abscesses","completionDate":"2012-02"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"MMSL":"4500","NDDF":"007042","UNII":"3GQ9E911BI","CHEBI":"CHEBI:134758","INN_ID":"2474","RXNORM":"215217","UMLSCUI":"C0772192","ChEMBL_ID":"CHEMBL2105833","KEGG_DRUG":"D05228","PUBCHEM_CID":"10982","MESH_SUPPLEMENTAL_RECORD_UI":"C000632592"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":16,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Jan 15","pmid":"39401652","title":"Heptaminol hair testing to highlight octodrine contamination in supplements, responsible for a doping adverse analytical finding.","journal":"Clinica chimica acta; international journal of clinical chemistry"},{"date":"2024 Nov","pmid":"38668840","title":"Synthesis and Analysis of Euphorbia cognata Boiss-Assisted Organic-Inorganic Complex: Photosynthesis and Stabilization of CoO Nanoparticles.","journal":"Applied biochemistry and biotechnology"},{"date":"2024 Feb 15","pmid":"38246007","title":"Application of a bar adsorptive microextraction based methodology for doping control of alkylamine stimulants in urine matrices.","journal":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences"},{"date":"2023 Aug","pmid":"37357012","title":"Unauthorized ingredients in \"nootropic\" dietary supplements: A review of the history, pharmacology, prevalence, international regulations, and potential as doping agents.","journal":"Drug testing and analysis"},{"date":"2022 Dec","pmid":"36569486","title":"Uncovering cloves: characterization of volatile compounds present in clove cigarettes.","journal":"Toxicology research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amidrine, also known as Octodrine, is a small molecule drug of the octodrine class. Its exact target and mechanism of action are unknown, but it is believed to work by stimulating the central nervous system. Amidrine is not FDA-approved for any indications, and its commercial status is unclear. As a result, there is limited information available on its safety profile and pharmacokinetic properties. Further research is needed to fully understand the potential benefits and risks of this compound.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}