{"id":"octenidine","rwe":[{"pmid":"41888683","year":"2026","title":"Preliminary study on the effects of sub-MIC concentrations of octenidine and polyhexanidine on biofilms produced by animal isolates of Pseudomonas aeruginosa.","finding":"","journal":"BMC microbiology","studyType":"Clinical Study"},{"pmid":"41878148","year":"2026","title":"Extending the architecture of bolaamphiphilic disinfectants: an investigation of octenidine and isooctenidine analogs.","finding":"","journal":"RSC medicinal chemistry","studyType":"Clinical Study"},{"pmid":"41858939","year":"2026","title":"Green RP-HPLC method for the simultaneous determination of octenidine and phenoxyethanol in antiseptic formulations: integration of a lean six sigma approach.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"41832823","year":"2026","title":"Mechanistic insights from dynamic structural changes of model bacterial cytoplasmic membranes challenged by Gemini surfactant octenidine.","finding":"","journal":"Journal of colloid and interface science","studyType":"Clinical Study"},{"pmid":"41831899","year":"2026","title":"Discovery of a novel compound against BmNPV using virtual screening based on the protein structure of the viral whole genome.","finding":"","journal":"Pesticide biochemistry and physiology","studyType":"Clinical Study"}],"tags":[{"label":"octenidine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A01AB24","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Infective Agents, Local","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["octenidine"],"offLabel":[],"synonyms":["octenidine"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"octenidine","explanation":"Imagine your skin as a battlefield where germs and bacteria try to invade. OCTENIDINE is like a special soldier that helps keep the bad guys from taking over by interfering with their ability to attach to and multiply on the skin. This helps to prevent infections and keep your skin healthy.","oneSentence":"OCTENIDINE works by disrupting the function of microorganisms on the skin.","technicalDetail":"OCTENIDINE exerts its antimicrobial effects by binding to and disrupting the function of microbial cell membranes, ultimately leading to cell death and prevention of infection."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3394","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=OCTENIDINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=OCTENIDINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T13:03:55.637001","biosimilars":[],"competitors":[{"drugName":"hydrogen peroxide","drugSlug":"hydrogen-peroxide","fdaApproval":"","patentExpiry":"Jul 4, 2035","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlorhexidine","drugSlug":"chlorhexidine","fdaApproval":"1976-09-17","patentExpiry":"Oct 2, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"amphotericin B","drugSlug":"amphotericin-b","fdaApproval":"1964-11-12","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxyquinoline","drugSlug":"oxyquinoline","fdaApproval":"","relationship":"same-class"},{"drugName":"neomycin","drugSlug":"neomycin","fdaApproval":"1957-03-26","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"miconazole","drugSlug":"miconazole","fdaApproval":"1974-01-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"natamycin","drugSlug":"natamycin","fdaApproval":"1978-10-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"tetracycline","drugSlug":"tetracycline","fdaApproval":"1953-11-19","genericCount":34,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"metronidazole","drugSlug":"metronidazole","fdaApproval":"1963-07-18","patentExpiry":"Oct 4, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlortetracycline","drugSlug":"chlortetracycline","fdaApproval":"1950-01-23","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"doxycycline","drugSlug":"doxycycline","fdaApproval":"1967-12-05","patentExpiry":"Dec 19, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"minocycline","drugSlug":"minocycline","fdaApproval":"1971-06-30","patentExpiry":"Sep 8, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"oxytetracycline","drugSlug":"oxytetracycline","fdaApproval":"1964-09-08","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"octenidine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrogen-peroxide","brandName":"hydrogen peroxide","genericName":"hydrogen peroxide","approvalYear":"","relationship":"same-class"},{"drugId":"chlorhexidine","brandName":"chlorhexidine","genericName":"chlorhexidine","approvalYear":"1976","relationship":"same-class"},{"drugId":"amphotericin-b","brandName":"amphotericin B","genericName":"amphotericin B","approvalYear":"1964","relationship":"same-class"},{"drugId":"oxyquinoline","brandName":"oxyquinoline","genericName":"oxyquinoline","approvalYear":"","relationship":"same-class"},{"drugId":"neomycin","brandName":"neomycin","genericName":"neomycin","approvalYear":"1957","relationship":"same-class"},{"drugId":"miconazole","brandName":"miconazole","genericName":"miconazole","approvalYear":"1974","relationship":"same-class"},{"drugId":"natamycin","brandName":"natamycin","genericName":"natamycin","approvalYear":"1978","relationship":"same-class"},{"drugId":"tetracycline","brandName":"tetracycline","genericName":"tetracycline","approvalYear":"1953","relationship":"same-class"},{"drugId":"metronidazole","brandName":"metronidazole","genericName":"metronidazole","approvalYear":"1963","relationship":"same-class"},{"drugId":"clotrimazole","brandName":"clotrimazole","genericName":"clotrimazole","approvalYear":"1975","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06276270","phase":"NA","title":"Multi-centre, Open-label, First-in-man Study With Mucopad HA","status":"COMPLETED","sponsor":"Contipro Pharma a.s.","startDate":"2023-12-12","conditions":["Oral Mucositis"],"enrollment":50,"completionDate":"2024-11-30"},{"nctId":"NCT06522438","phase":"NA","title":"Hyaluronic Acid and Octenidine Gel as an Adjunct to Non-surgical Periodontal Treatment","status":"RECRUITING","sponsor":"Queen Mary University of London","startDate":"2025-06-03","conditions":["Periodontitis","Wound Heal","Periodontal Pocket","Periodontal Inflammation","Periodontal Attachment Loss"],"enrollment":26,"completionDate":"2027-12-31"},{"nctId":"NCT07372677","phase":"NA","title":"Pocket-X Gel Non-surgical Periodontal Therapy","status":"RECRUITING","sponsor":"Universita di Verona","startDate":"2025-06-03","conditions":["Diabete Type 2"],"enrollment":70,"completionDate":"2030-01"},{"nctId":"NCT03140254","phase":"PHASE2","title":"Evaluating Safety and Effectiveness of Octenidine Dihydrochloride","status":"COMPLETED","sponsor":"C. R. Bard","startDate":"2016-09","conditions":["Preoperative Skin Preparation"],"enrollment":145,"completionDate":"2017-03-17"},{"nctId":"NCT07173725","phase":"NA","title":"The Effect of Using Octenidine Hydrochloride as a Final Irrigation Solution on Teeth With Asymptomatic Apical Periodontitis on Postoperative Pain and Treatment Success: A Prospective Randomized Clinical Study","status":"COMPLETED","sponsor":"Bezmialem Vakif University","startDate":"2023-03-08","conditions":["Apical Periodontitis","Postoperative Pain"],"enrollment":142,"completionDate":"2025-07-20"},{"nctId":"NCT06946719","phase":"NA","title":"Octenidine and Sodium Hypochlorite for Pulp Irrigation in Direct Pulp Capping","status":"ACTIVE_NOT_RECRUITING","sponsor":"Aydin Adnan Menderes University","startDate":"2024-06-01","conditions":["Pulp Exposure, Dental"],"enrollment":88,"completionDate":"2025-06-01"},{"nctId":"NCT06142591","phase":"PHASE4","title":"Oxycodone (10, 20 mg) in a Postoperative Dressing","status":"COMPLETED","sponsor":"Poznan University of Medical Sciences","startDate":"2016-01-01","conditions":["Burns"],"enrollment":20,"completionDate":"2022-03-03"},{"nctId":"NCT04325685","phase":"NA","title":"The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia","status":"COMPLETED","sponsor":"Northern State Medical University","startDate":"2020-01-01","conditions":["Trauma Injury","Brain Injuries","Abdominal Sepsis","Pancreatitis","Meningitis","Encephalitis","Seizures","Acute Respiratory Distress Syndrome"],"enrollment":60,"completionDate":"2023-11-07"},{"nctId":"NCT04172363","phase":"PHASE3","title":"Clinical Relevance of the Antimicrobial Resistance Testing in the Treatment of Chronic Wounds With Antiseptics","status":"WITHDRAWN","sponsor":"RWTH Aachen University","startDate":"2020-07-22","conditions":["Decubiti","Chronic Wounds","Acute Wounds"],"enrollment":0,"completionDate":"2021-05-22"},{"nctId":"NCT04985526","phase":"NA","title":"Skin Microbiome and Polymorphic Light Eruption","status":"UNKNOWN","sponsor":"Medical University of Graz","startDate":"2021-05-07","conditions":["Polymorphic Light Eruption"],"enrollment":30,"completionDate":"2023-06-30"},{"nctId":"NCT04846361","phase":"NA","title":"Vaginal Hygiene Wash as Adjunct Treatment in Bacterial Vaginosis","status":"UNKNOWN","sponsor":"Universiti Kebangsaan Malaysia Medical Centre","startDate":"2021-05","conditions":["Bacterial Vaginoses"],"enrollment":56,"completionDate":"2022-01"},{"nctId":"NCT03224299","phase":"PHASE2","title":"Effectiveness of an Antimicrobial Agent for Preoperative Skin Preparation","status":"COMPLETED","sponsor":"Becton, Dickinson and Company","startDate":"2017-06-21","conditions":["Preoperative Skin Preparation"],"enrollment":131,"completionDate":"2017-10-03"},{"nctId":"NCT03229759","phase":"PHASE2","title":"Evaluation of the Antimicrobial Effectiveness of an Antimicrobial Cloth","status":"COMPLETED","sponsor":"Becton, Dickinson and Company","startDate":"2017-06-21","conditions":["Preoperative Skin Preparation"],"enrollment":99,"completionDate":"2017-08-04"},{"nctId":"NCT02697162","phase":"PHASE2,PHASE3","title":"Antiseptic-coated Intermittent Urinary Catheter","status":"WITHDRAWN","sponsor":"Children's Hospital Zagreb","startDate":"2016-06","conditions":["Neurogenic Bladder","Catheter-Related Infections"],"enrollment":0,"completionDate":"2018-06"},{"nctId":"NCT04091399","phase":"PHASE2","title":"First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro","status":"COMPLETED","sponsor":"Contipro Pharma a.s.","startDate":"2015-09-11","conditions":["Alveolar Osteitis"],"enrollment":58,"completionDate":"2016-02-12"},{"nctId":"NCT03322124","phase":"PHASE3","title":"Study to Assess the Inhibition of Plaque Formation in Subjects With a Gingival Index ≤1.5","status":"COMPLETED","sponsor":"Schülke & Mayr GmbH","startDate":"2018-01-22","conditions":["Inhibition of Plaque Formation (by Gingivitis-Index ≤1.5)"],"enrollment":100,"completionDate":"2018-12-14"},{"nctId":"NCT03378401","phase":"PHASE3","title":"Study to Assess the Inhibition of Plaque Formation in Subjects With a Gingival Index ≤1.5","status":"COMPLETED","sponsor":"Schülke & Mayr GmbH","startDate":"2018-01-11","conditions":["Inhibition of Plaque Formation (by Gingivitis-Index ≤1.5)"],"enrollment":114,"completionDate":"2018-09-14"},{"nctId":"NCT01657292","phase":"PHASE3","title":"Oleogel-S10 Versus Standard of Care in Healing of Grade 2a Burn Wounds","status":"COMPLETED","sponsor":"Birken AG","startDate":"2012-08","conditions":["Burns"],"enrollment":61,"completionDate":"2014-07"},{"nctId":"NCT02169167","phase":"NA","title":"Comparison of Resin Salve and Octenidine in Patients With Neuropathic Diabetic Foot Ulcers","status":"COMPLETED","sponsor":"Janne J. Jokinen","startDate":"2014-06","conditions":["Diabetes Mellitus","Diabetes Complications","Diabetic Neuropathies","Wound Infection"],"enrollment":35,"completionDate":"2015-05"},{"nctId":"NCT02138552","phase":"PHASE2","title":"Dose Finding Study to Assess Octenidine Mouthwash Concentrations in Comparison to Placebo","status":"COMPLETED","sponsor":"Schülke & Mayr GmbH","startDate":"2013-10","conditions":["Gingivitis"],"enrollment":90,"completionDate":"2014-04"},{"nctId":"NCT01434914","phase":"PHASE4","title":"Study to Evaluate the Efficacy of Octenisept® in Patients With Chronic Wounds","status":"TERMINATED","sponsor":"Schülke & Mayr GmbH","startDate":"2011-10","conditions":["Ulcus Cruris"],"enrollment":9,"completionDate":"2013-07"},{"nctId":"NCT01096472","phase":"PHASE2","title":"Efficacy and Safety of LAS41003 in the Treatment of Inflammatory Tinea Pedis","status":"COMPLETED","sponsor":"Almirall, S.A.","startDate":"2010-02","conditions":["Tinea Pedis"],"enrollment":120,"completionDate":"2010-06"},{"nctId":"NCT01102387","phase":"PHASE2","title":"Efficacy and Safety of LAS41003 in the Treatment of Intertriginous Candida Infections","status":"COMPLETED","sponsor":"Almirall, S.A.","startDate":"2010-02","conditions":["Candidiasis"],"enrollment":137,"completionDate":"2011-07"},{"nctId":"NCT01020994","phase":"PHASE2","title":"Efficacy and Safety of LAS41003 in the Treatment of Superficial Infected Eczema","status":"COMPLETED","sponsor":"Almirall, S.A.","startDate":"2009-11","conditions":["Eczema"],"enrollment":150,"completionDate":"2010-06"},{"nctId":"NCT00515151","phase":"PHASE4","title":"Prevention of Catheter-Associated Infection With the Skin Disinfectant Octenidine Dihydrochloride","status":"COMPLETED","sponsor":"University Hospital Freiburg","startDate":"2002-05","conditions":["Catheterization, Central Venous","Catheter-Associated Infections","Bacterial Infections","Bacteremia"],"enrollment":400,"completionDate":"2005-04"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"014415","UNII":"OZE0372S5A","INN_ID":"4829","RXNORM":"2119240","UMLSCUI":"C0069351","ChEMBL_ID":"CHEMBL1199480","KEGG_DRUG":"D08289","DRUGBANK_ID":"DB12624","PUBCHEM_CID":"51167","MESH_SUPPLEMENTAL_RECORD_UI":"C034213"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":491,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"A01AB24","allCodes":["A01AB24","D08AJ57","G01AX66","R02AA21"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 26","pmid":"41888683","title":"Preliminary study on the effects of sub-MIC concentrations of octenidine and polyhexanidine on biofilms produced by animal isolates of Pseudomonas aeruginosa.","journal":"BMC microbiology"},{"date":"2026 Mar 4","pmid":"41878148","title":"Extending the architecture of bolaamphiphilic disinfectants: an investigation of octenidine and isooctenidine analogs.","journal":"RSC medicinal chemistry"},{"date":"2026 Mar 17","pmid":"41858939","title":"Green RP-HPLC method for the simultaneous determination of octenidine and phenoxyethanol in antiseptic formulations: integration of a lean six sigma approach.","journal":"RSC advances"},{"date":"2026 Mar 9","pmid":"41832823","title":"Mechanistic insights from dynamic structural changes of model bacterial cytoplasmic membranes challenged by Gemini surfactant octenidine.","journal":"Journal of colloid and interface science"},{"date":"2026 Apr","pmid":"41831899","title":"Discovery of a novel compound against BmNPV using virtual screening based on the protein structure of the viral whole genome.","journal":"Pesticide biochemistry and physiology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"OCTENIDINE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"OCTENIDINE is a small molecule drug in the octenidine class, developed by an unknown entity and currently owned by an unknown entity. Its target and exact mechanism of action are not specified. OCTENIDINE is used to treat unknown indications, and its commercial status, including patent status and generic availability, is unclear. Key safety considerations for OCTENIDINE are not well-documented. Further research is needed to fully understand this medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}