{"id":"oc-drospirenone-plus-ethynylestradiol","brandName":"OC - Drospirenone plus Ethynylestradiol","genericName":"OC - Drospirenone plus Ethynylestradiol","companyId":"federico-ii-university","companyName":"Federico II University","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Drospirenone and ethynylestradiol work together as a combined oral contraceptive by suppressing ovulation through progestin and estrogen activity. Used for Contraception / prevention of pregnancy, Acne vulgaris (in some formulations), Premenstrual dysphoric disorder (PMDD).","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ethinylestradiol is a synthetic estrogen that inhibits the luteinizing hormone (LH) surge needed for ovulation, while drospirenone is a progestin with antimineralocorticoid activity that further suppresses follicle-stimulating hormone (FSH) and thickens cervical mucus to prevent sperm penetration. Together, these hormones prevent pregnancy through multiple mechanisms including ovulation inhibition, cervical mucus thickening, and endometrial changes.","oneSentence":"Drospirenone and ethinylestradiol work together as an oral contraceptive by suppressing ovulation through progestin and estrogen activity.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"10-15","effect":"Nausea"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"5-15","effect":"Breakthrough bleeding"},{"rate":"2-5","effect":"Mood changes"},{"rate":"0.3-0.4","effect":"Venous thromboembolism"}]},"trials":[],"indications":{"approved":[{"name":"Contraception (pregnancy prevention)"},{"name":"Acne vulgaris (in some formulations)"},{"name":"Premenstrual dysphoric disorder (PMDD)"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}