{"id":"obidoxime","rwe":[],"tags":[{"label":"obidoxime","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Acetylcholinesterase","category":"target"},{"label":"ACHE","category":"gene"},{"label":"V03AB13","category":"atc"},{"label":"Active","category":"status"},{"label":"Organophosphate poisoning","category":"indication"},{"label":"Cholinergic Agents","category":"pharmacology"},{"label":"Cholinesterase Reactivators","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"obidoxim","offLabel":[],"synonyms":["obidoxime","obidoxime chloride","toxogonin","obidoxim"],"timeline":[],"approvals":[],"brandName":"Obidoxim","ecosystem":[{"indication":"Organophosphate poisoning","otherDrugs":[{"name":"pralidoxime","slug":"pralidoxime","company":"Baxter Hlthcare Corp"}],"globalPrevalence":null}],"mechanism":{"target":"Acetylcholinesterase","targets":[{"gene":"ACHE","source":"DrugCentral","target":"Acetylcholinesterase","protein":"Acetylcholinesterase"}],"modality":"Small Molecule","drugClass":"obidoxime","explanation":"Think of acetylcholine like a key that unlocks muscles to move. When Organophosphate poisoning occurs, it blocks the key from working, causing muscles to become paralyzed. Obidoxim acts like a special tool that removes the blockage, allowing the key to work again and restoring muscle function.","oneSentence":"Obidoxim works by reactivating Acetylcholinesterase, an enzyme that breaks down acetylcholine, a neurotransmitter.","technicalDetail":"Obidoxim is a cholinesterase reactivator that specifically targets the phosphylated acetylcholinesterase enzyme, restoring its enzymatic activity and facilitating the breakdown of acetylcholine."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4676","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=OBIDOXIME","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=OBIDOXIME","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:06:47.994332","biosimilars":[],"competitors":[{"drugName":"nalorphine","drugSlug":"nalorphine","fdaApproval":"","relationship":"same-class"},{"drugName":"pralidoxime","drugSlug":"pralidoxime","fdaApproval":"1964-03-11","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"prednisolone","drugSlug":"prednisolone","fdaApproval":"1955-06-21","genericCount":42,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"promethazine","drugSlug":"promethazine","fdaApproval":"1951-03-29","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sodium nitrite","drugSlug":"sodium-nitrite","fdaApproval":"2011-01-14","patentExpiry":"Feb 10, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"dimercaprol","drugSlug":"dimercaprol","fdaApproval":"1946-05-06","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"protamine sulfate","drugSlug":"protamine-sulfate","fdaApproval":"1969-08-13","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"naloxone","drugSlug":"naloxone","fdaApproval":"1971-04-13","patentExpiry":"Oct 30, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"ethanol","drugSlug":"ethanol","fdaApproval":"1946-01-17","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"methylthioninium chloride","drugSlug":"methylthioninium-chloride","fdaApproval":"","relationship":"same-class"},{"drugName":"copper sulfate","drugSlug":"copper-sulfate","fdaApproval":"1987-05-05","relationship":"same-class"},{"drugName":"potassium iodide","drugSlug":"potassium-iodide","fdaApproval":"1979-11-09","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"amyl nitrite","drugSlug":"amyl-nitrite","fdaApproval":"","relationship":"same-class"},{"drugName":"acetylcysteine","drugSlug":"acetylcysteine","fdaApproval":"1963-09-14","patentExpiry":"May 8, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"flumazenil","drugSlug":"flumazenil","fdaApproval":"1991-12-20","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methionine","drugSlug":"methionine","fdaApproval":"","relationship":"same-class"},{"drugName":"prussian blue","drugSlug":"prussian-blue","fdaApproval":"2003-10-02","relationship":"same-class"},{"drugName":"hydroxocobalamin","drugSlug":"hydroxocobalamin","fdaApproval":"1978-08-16","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fomepizole","drugSlug":"fomepizole","fdaApproval":"1997-12-04","patentExpiry":"Jun 30, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sugammadex","drugSlug":"sugammadex","fdaApproval":"2015-12-15","patentExpiry":"Jul 27, 2026","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"obidoxime","indications":{"approved":[{"name":"Organophosphate poisoning","source":"DrugCentral","snomedId":8260003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nalorphine","brandName":"nalorphine","genericName":"nalorphine","approvalYear":"","relationship":"same-class"},{"drugId":"pralidoxime","brandName":"pralidoxime","genericName":"pralidoxime","approvalYear":"1964","relationship":"same-class"},{"drugId":"prednisolone","brandName":"prednisolone","genericName":"prednisolone","approvalYear":"1955","relationship":"same-class"},{"drugId":"promethazine","brandName":"promethazine","genericName":"promethazine","approvalYear":"1951","relationship":"same-class"},{"drugId":"sodium-nitrite","brandName":"sodium nitrite","genericName":"sodium nitrite","approvalYear":"2011","relationship":"same-class"},{"drugId":"dimercaprol","brandName":"dimercaprol","genericName":"dimercaprol","approvalYear":"1946","relationship":"same-class"},{"drugId":"protamine-sulfate","brandName":"protamine sulfate","genericName":"protamine sulfate","approvalYear":"1969","relationship":"same-class"},{"drugId":"naloxone","brandName":"naloxone","genericName":"naloxone","approvalYear":"1971","relationship":"same-class"},{"drugId":"ethanol","brandName":"ethanol","genericName":"ethanol","approvalYear":"1946","relationship":"same-class"},{"drugId":"methylthioninium-chloride","brandName":"methylthioninium chloride","genericName":"methylthioninium chloride","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05006638","phase":"PHASE4","title":"Assessing The Role Of Intravenous Lipid Emulsion As A Life Saving Therapy In Pesticides Toxicity","status":"UNKNOWN","sponsor":"Aya Sabry Mohamed Mohamed","startDate":"2022-12","conditions":["Pesticide Poisoning"],"enrollment":62,"completionDate":"2023-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006771","UNII":"N6KNE1QA9O","INN_ID":"2138","RXNORM":"42826","UMLSCUI":"C0086728","ChEMBL_ID":"CHEMBL451635","KEGG_DRUG":"D05215","DRUGBANK_ID":"DB13750","PDB_CHEM_ID":"OBI","PUBCHEM_CID":"135412781","SNOMEDCT_US":"1156231009","SECONDARY_CAS_RN":"114-90-9","MESH_DESCRIPTOR_UI":"D009768"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"1.2 hours","clearance":"1.9 mL/min/kg","volumeOfDistribution":"0.17 L/kg"},"publicationCount":520,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"V03AB13","allCodes":["V03AB13"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Obidoxim (OBIDOXIME) is a small molecule obidoxime drug that targets Acetylcholinesterase. It is used to treat Organophosphate poisoning. The commercial status of Obidoxim is unclear, and it is not FDA approved. Obidoxim has a half-life of 1.2 hours, but its bioavailability is unknown. It is owned by an unknown entity, originally developed by an unknown entity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}