{"id":"nystatin-10000u-ml","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Local irritation or burning (topical)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nystatin is a polyene macrolide antibiotic that selectively targets ergosterol, a sterol unique to fungal cell membranes. By binding to ergosterol, it disrupts membrane integrity and increases permeability, leading to loss of cellular contents and fungal cell death. It is fungicidal and has minimal effect on mammalian cells due to their reliance on cholesterol rather than ergosterol.","oneSentence":"Nystatin binds to ergosterol in fungal cell membranes, creating pores that cause leakage and cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:01.772Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral candidiasis (thrush)"},{"name":"Cutaneous and mucocutaneous candida infections"},{"name":"Intestinal candidiasis"}]},"trialDetails":[{"nctId":"NCT02662374","phase":"PHASE4","title":"Oral Hygiene Regimen in Patients on HCT","status":"UNKNOWN","sponsor":"Riyadh Colleges of Dentistry and Pharmacy","startDate":"2015-09","conditions":"Oral Mucositis","enrollment":45}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Mycostatin (Amman Pharmacuetical Corp. Amman, Jordan"],"phase":"marketed","status":"active","brandName":"Nystatin 10000U/ml","genericName":"Nystatin 10000U/ml","companyName":"Riyadh Colleges of Dentistry and Pharmacy","companyId":"riyadh-colleges-of-dentistry-and-pharmacy","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nystatin binds to ergosterol in fungal cell membranes, creating pores that cause leakage and cell death. Used for Oral candidiasis (thrush), Cutaneous and mucocutaneous candida infections, Intestinal candidiasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}