{"id":"nw-roselle","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Roselle contains polyphenols and anthocyanins that act as free radical scavengers and may modulate inflammatory pathways. The extract is traditionally used in herbal medicine for potential cardiovascular and metabolic benefits, though the precise molecular mechanisms in humans remain incompletely characterized.","oneSentence":"NW Roselle is a botanical extract from Hibiscus sabdariffa (roselle plant) that may exert antioxidant and anti-inflammatory effects.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:23:45.761Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension or cardiovascular health (presumed, based on phase 3 status and traditional use)"}]},"trialDetails":[{"nctId":"NCT06141200","phase":"PHASE3","title":"NW Roselle in Grade 1 Essential Hypertension: Phase III Clinical Trial","status":"UNKNOWN","sponsor":"Natural Wellness Egypt","startDate":"2024-03","conditions":"Essential Hypertension","enrollment":286}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"NW Roselle","genericName":"NW Roselle","companyName":"Natural Wellness Egypt","companyId":"natural-wellness-egypt","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NW Roselle is a protein-based intervention being studied in a Phase III clinical trial for the treatment of Grade 1 Essential Hypertension. The trial is comparing NW Roselle to Captopril 25Mg Tab in patients with Grade 1 Essential Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}