{"id":"nulytely","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Nausea"},{"rate":"10-20","effect":"Abdominal bloating"},{"rate":"10-20","effect":"Abdominal cramping"},{"rate":"5-15","effect":"Vomiting"},{"rate":"5-10","effect":"Anal irritation"}]},"_chembl":{"chemblId":"CHEMBL1201479","moleculeType":"Small molecule"},"_dailymed":{"setId":"b630fb8f-b6aa-4b94-a93c-d79f1626c05b","title":"NULYTELY (PEG-3350, SODIUM CHLORIDE, SODIUM BICARBONATE AND POTASSIUM CHLORIDE) POWDER, FOR SOLUTION [PHYSICIANS TOTAL CARE, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"NuLytely contains polyethylene glycol (PEG) 3350, an osmotically active compound that retains water in the intestinal lumen, increasing stool bulk and promoting bowel movements. The solution is formulated with electrolytes (sodium, potassium, chloride, bicarbonate) to maintain electrolyte balance while the osmotic effect cleanses the colon. This mechanism makes it effective for bowel preparation prior to colonoscopy or other gastrointestinal procedures.","oneSentence":"NuLytely is an osmotic laxative solution that draws water into the bowel to promote bowel evacuation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:57:54.311Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel preparation prior to colonoscopy"},{"name":"Bowel preparation prior to barium enema or other gastrointestinal procedures"}]},"trialDetails":[{"nctId":"NCT02661750","phase":"","title":"Safety and Efficacy of High Dose Bowel Preparation Solutions for Patients With Difficult To Clean Colons For Colonoscopy","status":"COMPLETED","sponsor":"Gastroenterology Services, Ltd.","startDate":"2016-01","conditions":"Preparation for Colonoscopy","enrollment":79},{"nctId":"NCT01631435","phase":"PHASE1, PHASE2","title":"PillCam® Platform With the PillCam Crohn's Disease Capsule","status":"COMPLETED","sponsor":"Medtronic - MITG","startDate":"2012-06","conditions":"Crohn's Disease","enrollment":75},{"nctId":"NCT02402270","phase":"PHASE2","title":"Safety and Tolerability Study of an Edible Colon Preparation","status":"COMPLETED","sponsor":"ColonaryConcepts LLC","startDate":"2015-05","conditions":"Bowel Preparation","enrollment":69},{"nctId":"NCT01170754","phase":"PHASE4","title":"Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy","status":"COMPLETED","sponsor":"Temple University","startDate":"2010-04","conditions":"Colon Cancer","enrollment":136},{"nctId":"NCT00689026","phase":"NA","title":"Efficacy of Lubiprostone in Combination With Standard PEG Preparation","status":"TERMINATED","sponsor":"Augusta University","startDate":"2008-05","conditions":"Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2","enrollment":60},{"nctId":"NCT01063049","phase":"PHASE4","title":"Gatorade/Miralax With or Without Bisacodyl Versus NuLytely for Colonoscopy Preparation","status":"COMPLETED","sponsor":"Gastroenterology Services, Ltd.","startDate":"2010-02","conditions":"Preparation for Colonoscopy","enrollment":600},{"nctId":"NCT01929590","phase":"PHASE3","title":"Low-volume Polyethylene Glycol Bowel Preparation for Colonoscopy","status":"COMPLETED","sponsor":"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","startDate":"2011-10","conditions":"Bowel Preparation for Colonoscopy","enrollment":180},{"nctId":"NCT00164164","phase":"PHASE3","title":"HalfLytely Bowel Prep System for Colonoscopy","status":"COMPLETED","sponsor":"Braintree Laboratories","startDate":"1999-08","conditions":"Colonoscopy","enrollment":200},{"nctId":"NCT00164151","phase":"PHASE3","title":"A Comparison of the Efficacy and Safety of HalfLytely Vs Visicol Prior To Colonoscopy.","status":"COMPLETED","sponsor":"Braintree Laboratories","startDate":"2001-06","conditions":"Colonoscopy","enrollment":60},{"nctId":"NCT00953043","phase":"PHASE4","title":"Lubiprostone, Colonic Motility and Sensation","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2007-09","conditions":"Healthy","enrollment":60},{"nctId":"NCT00425594","phase":"PHASE4","title":"A Safety and Efficacy Evaluation of 3 Bowel Preparations in the Pediatric Population","status":"COMPLETED","sponsor":"Braintree Laboratories","startDate":"2007-01","conditions":"Colonoscopy","enrollment":150}],"_emaApprovals":[],"_faersSignals":[{"count":68,"reaction":"VOMITING"},{"count":52,"reaction":"NAUSEA"},{"count":46,"reaction":"FALL"},{"count":44,"reaction":"CONFUSIONAL STATE"},{"count":44,"reaction":"DRUG INTERACTION"},{"count":44,"reaction":"DYSPNOEA"},{"count":41,"reaction":"DIZZINESS"},{"count":38,"reaction":"DIARRHOEA"},{"count":38,"reaction":"HYPONATRAEMIA"},{"count":37,"reaction":"PNEUMONIA"}],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"NuLytely","genericName":"NuLytely","companyName":"Gastroenterology Services, Ltd.","companyId":"gastroenterology-services-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"NuLytely is an osmotic laxative solution that draws water into the bowel to promote bowel evacuation. Used for Bowel preparation prior to colonoscopy, Bowel preparation prior to barium enema or other gastrointestinal procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}