{"id":"nucleotides-b12","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nucleotides (adenine, guanine, cytosine, thymine, uracil derivatives) serve as precursors for nucleic acid synthesis and cellular energy metabolism. Vitamin B12 is an essential cofactor for methionine synthase and methylmalonyl-CoA mutase, critical for DNA synthesis, myelin formation, and erythropoiesis. Together, this combination supports cellular proliferation and hematopoietic function.","oneSentence":"Nucleotides provide building blocks for DNA and RNA synthesis, while B12 (cobalamin) supports methylation reactions and red blood cell formation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:58:04.099Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nutritional supplementation for nucleotide and B12 deficiency"},{"name":"Support for hematopoiesis and cellular metabolism"}]},"trialDetails":[{"nctId":"NCT07475546","phase":"PHASE3","title":"Combination Gerotherapeutic Interventions for Healthspan Improvement","status":"ACTIVE_NOT_RECRUITING","sponsor":"AgelessRx","startDate":"2025-07-23","conditions":"Healthspan Improvement, Aging, Longevity","enrollment":30},{"nctId":"NCT07304453","phase":"PHASE2","title":"Nucleo CMP and Neurorubine Versus Carbamazepine for Classical Trigeminal Neuralgia","status":"COMPLETED","sponsor":"Karbala University","startDate":"2024-01-07","conditions":"Trigeminal Neuralgia, Neuropathic Pain","enrollment":38},{"nctId":"NCT07296354","phase":"PHASE4","title":"Evaluation of an ATP-Containing Parenteral Vitamin B Complex in Patients With Symptomatic Diabetic Polyneuropathy","status":"NOT_YET_RECRUITING","sponsor":"Egyptian International Pharmaceutical Industries Co","startDate":"2026-01-10","conditions":"Neuropathic Pain","enrollment":200},{"nctId":"NCT02711137","phase":"PHASE1, PHASE2","title":"Open-Label Safety and Tolerability Study of INCB057643 in Subjects With Advanced Malignancies","status":"TERMINATED","sponsor":"Incyte Corporation","startDate":"2016-05-18","conditions":"Solid Tumors","enrollment":137},{"nctId":"NCT05536596","phase":"PHASE2, PHASE3","title":"Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy","status":"UNKNOWN","sponsor":"Universitat Internacional de Catalunya","startDate":"2022-09-30","conditions":"Retrognathism, Prognathism, Orthognathic Surgery","enrollment":220},{"nctId":"NCT05527106","phase":"NA","title":"Evaluation of the Effect of Citicoline and Docosahexaenoic Acid (DHA) on the Visual Function of Patients With Glaucoma","status":"COMPLETED","sponsor":"Institut Catala de Retina","startDate":"2015-03-12","conditions":"Glaucoma","enrollment":73},{"nctId":"NCT03161223","phase":"PHASE1, PHASE2","title":"Durvalumab in Different Combinations With Pralatrexate, Romidepsin and Oral 5-Azacitidine for Lymphoma","status":"RECRUITING","sponsor":"University of Virginia","startDate":"2018-05-30","conditions":"Lymphoma, T-Cell","enrollment":148},{"nctId":"NCT02625909","phase":"PHASE3","title":"Randomised Study of Interferon-free Treatment for Recently Acquired Hepatitis C in PWID and People With HIV Coinfection.","status":"COMPLETED","sponsor":"Kirby Institute","startDate":"2017-03-09","conditions":"Hepatitis C","enrollment":222},{"nctId":"NCT01717326","phase":"PHASE2","title":"A Study of the Combination Regimen Grazoprevir (MK-5172) and Elbasvir (MK-8742) ± Ribavirin in Participants With Chronic Hepatitis C (MK-5172-035)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2013-02-07","conditions":"Hepatitis C","enrollment":573},{"nctId":"NCT02332720","phase":"PHASE2","title":"Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Virus (HCV) Genotype (GT) 3, GT4, GT5, and GT6 Infection (MK-3682-012)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2015-01-28","conditions":"Hepatitis C","enrollment":413},{"nctId":"NCT02332707","phase":"PHASE2","title":"Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and GT2 Infection (MK-3682-011)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2015-01-22","conditions":"Hepatitis C","enrollment":443},{"nctId":"NCT02640417","phase":"PHASE4","title":"Nucleotides and B Vitamins in the Treatment of Low Back Pain","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2016-03","conditions":"Low Back Pain","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1159,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Group A"],"phase":"marketed","status":"active","brandName":"Nucleotides + B12","genericName":"Nucleotides + B12","companyName":"Fundação Educacional Serra dos Órgãos","companyId":"funda-o-educacional-serra-dos-rg-os","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nucleo CMP and Neurorubine combination therapy has been studied for its potential in treating classical trigeminal neuralgia, with one clinical trial suggesting it provides sustained long-term pain control compared to conventional carbamazepine therapy. Additionally, this combination has been investigated in clinical trials for other conditions, including neuropathic pain, hepatitis C, lymphoma, and T-cell conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}