{"id":"nucleos-t-tide-analogues","safety":{"commonSideEffects":[{"rate":null,"effect":"Lactic acidosis"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Mitochondrial toxicity"}]},"_chembl":{"chemblId":"CHEMBL7652","moleculeType":"Small molecule","molecularWeight":"414.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"These drugs are nucleoside or nucleotide derivatives that are incorporated into viral DNA or RNA during replication, causing chain termination and blocking further viral genome synthesis. They are commonly used to treat infections caused by retroviruses (HIV) and hepatitis viruses (HBV, HCV) by reducing viral load and slowing disease progression.","oneSentence":"Nucleos(t)ide analogues inhibit viral reverse transcriptase and/or polymerase enzymes, preventing viral nucleic acid synthesis and replication.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:57:52.883Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic hepatitis B infection"},{"name":"HIV infection"},{"name":"Chronic hepatitis C infection (select agents)"}]},"trialDetails":[{"nctId":"NCT02982837","phase":"PHASE4","title":"To Study the Effect of Adding on Pegylated Interferon (PEG-INF) Therapy for Patients Diagnosed With Chronic Hepatitis B","status":"UNKNOWN","sponsor":"King Abdullah International Medical Research Center","startDate":"2015-03","conditions":"Hepatitis B","enrollment":214}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Nucleoside/nucleotide analogues"],"phase":"marketed","status":"active","brandName":"Nucleos(t)tide analogues","genericName":"Nucleos(t)tide analogues","companyName":"King Abdullah International Medical Research Center","companyId":"king-abdullah-international-medical-research-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nucleos(t)ide analogues inhibit viral reverse transcriptase and/or polymerase enzymes, preventing viral DNA synthesis and replication. Used for Chronic hepatitis B, HIV infection, Chronic hepatitis C (in combination regimens).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}